Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer

Chuqian Lei; Ciqiu Yang; Bin Xia; Fei Ji; Yi Zhang; Hongfei Gao; Qianqian Xiong; Yufeng Lin; Xiaosheng Zhuang; Liulu Zhang; Teng Zhu; Minyi Cheng; Mei Yang; Kun Wang

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저자정보: Chuqian Lei (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Acad) Ciqiu Yang (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Bin Xia (Clinical Research Center The Seventh Affiliated Hospital Sun Yat-sen University Shenzhen Guangdo) Fei Ji (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Yi Zhang (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Hongfei Gao (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Qianqian Xiong (Department of General Surgery Shenzhen Tradition Chinese Medicine Hospital Shenzhen China) Yufeng Lin (Department of General Surgery Zhuhai Golden Bay Center Hospital Zhuhai China) Xiaosheng Zhuang (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Liulu Zhang (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Teng Zhu (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Minyi Cheng (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Mei Yang (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Academ) Kun Wang (Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital China)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.1

발행연도: 2020.1

수록면: 47 - 58 (12page)

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Purpose: Tau is a microtubule-associated protein that can be found in both normal and abnormal breast cells. Whether the expression of Tau protein can predict the response to neoadjuvant chemotherapy (NACT) is still unclear. In this study, we assessed the role of Tau protein expression in predicting a pathological complete response (pCR) to NACT for different subtypes of breast cancer. Methods: Four hundred and sixty-eight eligible patients were retrospectively recruited in our study. The relationship between clinicopathologic factors, including Tau protein expression, and pCR in different subtypes was evaluated using logistic regression analysis. Correlation between Tau and disease-free survival (DFS) and overall survival (OS) was performed using Kaplan–Meier analysis. Results: The expression of Tau protein was negatively correlated with pCR, especially in triple-negative breast cancer (TNBC). No significant difference was observed in the luminal human epidermal growth factor receptor-2 (HER2)-negative subtype and HER2-positive subtype. Patients with pCR were associated with better DFS and OS (p < 0.05). However, Tau protein expression had no association with either DFS or OS (p > 0.05). Conclusion: Tau protein expression can predict pCR before NACT in TNBC, but there was no correlation between Tau expression and DFS or OS.

#Neoadjuvant therapy #Survival #Tau proteins #Triple negative breast neoplasms

참고문헌 (28)

참고문헌 신청

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Gradishar WJ / 2018 / Breast cancer, version 4.2017, NCCN clinical practice guidelines in oncology / J Natl Compr Canc Netw 16:310~320

Kaufmann M / 2007 / Recommendations from an international expert panel on the use of neoadjuvant(primary)systemic treatment of operable breast cancer : new perspectives 2006 / Ann Oncol 18:1927~1934

Andre F / 2007 / Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer / Clin Cancer Res 13:2061~2067

Cortazar P / 2014 / Pathological complete response and long-term clinical benefit in breast cancer : the CTNeoBC pooled analysis / Lancet 384:164~172

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Chuqian Lei

소속기관 Department of Breast Cancer Cancer Center Guangdong Provincial People's Hospital Guangdong Acad