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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.3
- 수록면
- 1 - 5 (5page)
- DOI
- 10.20307/nps.2022.28.1.1
이용수
초록· 키워드
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Two 2H-1-benzopyran derivatives, methyl 8-hydroxy-2,2-dimethyl-2H-1-benzopyran-5-carboxylate (1) and methyl 8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carboxylate (2), including a new compound (1) were isolated from the twigs of Chaenomeles sinensis. Their chemical structures were characterized based on analysis of NMR data including <SUP>1</SUP>H and <SUP>13</SUP>C, COSY, HSQC, and HMBC and HRMS data. The isolated compounds (1 and 2) were assessed for their anti-neuroinflammatory activity by measuring inhibition levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells and for their neurotrophic activity by the secretion of nerve growth factor (NGF) in C6 cells. Compounds 1 and 2 exhibited powerful anti-neuroinflammatory effects with IC<SUB>50 </SUB>values of 17.14 and 19.30 μM, respectively, without cell toxicity, and also showed moderate effects on the stimulation of NGF secretion levels with 113.15 ± 3.54 and 130.20 ± 8.03%, respectively. The biosynthetic pathway of 1 and 2 was proposed that they would be derived from a protocatechuic acid and an isoprenyl unit.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
참고문헌 (19)
참고문헌 신청
Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R. J. Nat. Prod. 2015, 78, 1174-1178.
Mihara, S.; Tateba, H.; Nishimura, O.; Machii, Y.; Kishino, K. J. Agric. Food Chem. 1987, 35, 532-537.
Lee, M. H.; Han, Y. N. Planta Med. 2003, 69, 327-331.
Gao, H.; Wu, L .; Kuroyanagi, M .; Harada, K .; Kawahara, N .; Nakane, T.; Umehara, K.; Hirasawa, A.; Nakamura, Y. Chem. Pharm. Bull. 2003, 51, 1318-1321.
Osawa, K.; Yasuda, H.; Morita, H.; Takeya, K.; Itokawa, H. Nat. Med. 1997, 51, 365-367.
Mihara, S.; Tateba, H.; Nishimura, O.; Machii, Y.; Kishino, K. J. Agric. Food Chem. 1987, 35, 532-537.
Lee, M. H.; Han, Y. N. Planta Med. 2003, 69, 327-331.
Gao, H.; Wu, L .; Kuroyanagi, M .; Harada, K .; Kawahara, N .; Nakane, T.; Umehara, K.; Hirasawa, A.; Nakamura, Y. Chem. Pharm. Bull. 2003, 51, 1318-1321.
Osawa, K.; Yasuda, H.; Morita, H.; Takeya, K.; Itokawa, H. Nat. Med. 1997, 51, 365-367.
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