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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 179 - 186 (8page)
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초록· 키워드
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Pyrrosia lingua which belongs to Polypodiaceae has been used as a traditional medicine for the treatment of urinary system inflammation, urination disorder, and bronchitis. However, there are not enough phytochemical and pharmacological studies of P. lingua up to now. Here in this study, the protective effect of MeOH extract of whole plant of Pyrrosia lingua (MPL) against 2% glucose-induced toxicity was investigated using Caenorhabditis elegans (C. elegans) model system. We found that MPL significantly extended the lifespan of wild-type nematode under normal culture condition. MPL also effectively recovered the decreased lifespan caused by 2% glucose-toxicity. In addition, MPL efficiently attenuated the increased glucose concentration inside of nematode. Further studies evaluating diabetes-related factors revealed that MPL reduced both intracellular ROS and lipid accumulation which were up-regulated under 2% glucose supplement condition. Our data also showed that MPL improved the 2% glucose-induced shortened body movement of nematode. Lastly, we carried out genetic studies using several single gene knockout mutants to establish the possible target of MPL. Our results demonstrated that genes such as daf-2 and daf-16 were responsible for the protective activity of MPL against 2% glucose-induced toxicity. These results indicate that MPL exerts protective action against 2% glucose via regulation of insulin/IGF-1 sinaling pathway and FOXO activation.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Canivell, S. / 2014 / Diagnosis and classification of autoimmune diabetes mellitus / Autoimmunity Reviews 13:403~407
Gavin III, J. R. / 1997 / Report of the expert committee on the diagnosis and classification of diabetes mellitus / Diabetes Care 20:1183
Chiang, J. L. / 2014 / Type 1 diabetes through the life span : a position statement of the American Diabetes Association / Diabetes Care 37:2034~2054
Asano, N. / 2001 / Polyhydroxylated alkaloids isolated from mulberry trees(Morus alba L. )and silkworms(Bombyx mori L.) / J. Agric. Food Chem 49:4208~4213
Do, J. C. / 1992 / Notes; Flavonoid Glycosides from the Fronds of Pyrrosia lingua / Kor. J. Pharmacogn 23:276~279
Gavin III, J. R. / 1997 / Report of the expert committee on the diagnosis and classification of diabetes mellitus / Diabetes Care 20:1183
Chiang, J. L. / 2014 / Type 1 diabetes through the life span : a position statement of the American Diabetes Association / Diabetes Care 37:2034~2054
Asano, N. / 2001 / Polyhydroxylated alkaloids isolated from mulberry trees(Morus alba L. )and silkworms(Bombyx mori L.) / J. Agric. Food Chem 49:4208~4213
Do, J. C. / 1992 / Notes; Flavonoid Glycosides from the Fronds of Pyrrosia lingua / Kor. J. Pharmacogn 23:276~279
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