지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 272 - 278 (7page)
- DOI
- 10.7841/ksbbj.2021.36.4.272
이용수
초록· 키워드
오류제보하기
Bone is an important organ that plays a crucial role in protecting other internal organs, producing blood cells, and maintaining blood calcium homeostasis. Diseases such as bone fractures and osteoporosis that cause bone dysfunction can seriously impair patient"s life quality. Recently, transplantation of the osteoblast-embedded three-dimensional hydrogels has been studied as means for bone regeneration. In this study, macroporous gelatin cryogel was fabricated to promote osteoblast differentiation. The interconnected macroporosity of gelatin cryogel was confirmed by scanning electron microscope and the swelling ratio of the gel was determined using dried swollen gel weight. Next, the osteogenic differentiation of bone marrowderived human mesenchymal stem cells and the direct conversion of human dermal fibroblasts into osteoblasts were performed in the fabricated macroporous gelatin cryogel and the efficiencies were compared with those in Matrigel, respectivley. Quantitative analysis of calcium deposition demonstrated that the functional osteoblasts were generated with higher efficiency in the macroporous gelatin cryogel than in Matrigel. Consequently, these results suggest that the macroporous gelatin cryogel has a great potential as biomaterial scaffold for efficient bone tissue engineering.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (45)
참고문헌 신청
Porter, J. R. / 2009 / Bone tissue engineering : a review in bone biomimetics and drug delivery strategies / Biotechnol. Prog 25:1539~1560
Bliuc, D. / 2009 / Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women / JAMA 301:513~521
Vestergaard, P. / 2007 / Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications / Osteoporos. Int 18:1583~1593
Venugopal, J. R. / 2008 / Nanobioengineered electrospun composite nanofibers and osteoblasts for bone regeneration / Artif. Organs 32:388~397
Tahmasebi, A. / 2020 / Micro-RNA-incorporated electrospun nanofibers improve osteogenic differentiation of human-induced pluripotent stem cells / J. Biomed. Mater. Res. A 108:377~386
Bliuc, D. / 2009 / Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women / JAMA 301:513~521
Vestergaard, P. / 2007 / Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications / Osteoporos. Int 18:1583~1593
Venugopal, J. R. / 2008 / Nanobioengineered electrospun composite nanofibers and osteoblasts for bone regeneration / Artif. Organs 32:388~397
Tahmasebi, A. / 2020 / Micro-RNA-incorporated electrospun nanofibers improve osteogenic differentiation of human-induced pluripotent stem cells / J. Biomed. Mater. Res. A 108:377~386
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UCI(KEPA) : I410-ECN-0101-2022-470-001516961