지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.2
- 수록면
- 83 - 92 (10page)
- DOI
- 10.1007/s13770-021-00416-2
이용수
초록· 키워드
오류제보하기
Background: Due to the increasing aging of society, the number of patients suffering from senile diseases is increasing. Patients suffering from osteoporosis, which is a representative senile disease, take a long time to recover from fractures, and the resulting mortality rate is very high. Alendronate (Ald), which is widely used as a treatment for osteoporosis, alleviates osteoporosis by inhibiting osteoclasts. In addition, whitlockite (WH) promotes the osteogenic differentiation of bone cells and improves bone regeneration. Therefore, we intended to bring about a synergistic effect by using these substances together.
Methods: In this study, a scaffold composed of gelatin/heparin was fabricated and applied to effectively use WH and Ald together. A scaffold was constructed using gelatin and heparin was used to effectively utilize the cations released from WH. In addition, it formed a porous structure for effective bone regeneration. In vitro and in vivo osteoclast inhibition, osteogenic differentiation, and bone regeneration were studied using the prepared scaffolds.
Results: The inhibition of osteoclast was much higher when WH and Ald were applied in combination rather than individually. The highest level of osteogenic differentiation was observed when both substances were applied simultaneously. In addition, when applied to bone regeneration through the mouse calvarial defect model, combined treatment showed excellent bone regeneration.
Conclusion: Therefore, this study showed the synergistic effect of WH and Ald, and it is suggested that better bone regeneration is possible by applying this treatment to bones with fractures that are difficult to regenerate.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Paper-based Scaffold for Stem Cell Culture and Bone Regeneration
한국고분자학회 학술대회 연구논문 초록집
2015 .04
-
Cell-encapsulated Gelatin/β-Tricalcium phosphate Photocurable Hydrogel Scaffold for Bone Regeneration
한국생물공학회 학술대회
2017 .10
-
Pilot study on patient-specific bone scaffold using 2-D femur image
대한기계학회 춘추학술대회
2021 .04
-
Natural Polymer Bone Scaffold for Enhanced Bone Regeneration
한국생물공학회 학술대회
2017 .04
-
Development of new composite scaffolds for bone tissue engineering
대한기계학회 춘추학술대회
2015 .05
-
Direct conversion of fibroblasts to osteoblasts as a novel strategy for bone regeneration in elderly individuals
Experimental and Molecular Medicine
2019 .01
-
Fabrication of various composite scaffolds for bone tissue engineering
대한기계학회 춘추학술대회
2015 .11
-
Functionalized Microparticles with Signaling Molecules and Stem Cells for Enhanced Bone Regeneration
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
적층제조를 활용한 골재생용 세포지지체 제작의 효용성 강화를 위한 몇 가지 방법에 대한 소고
한국정밀공학회 학술발표대회 논문집
2023 .05
-
Structural Behavior Analysis according to Porous Structures of the Bone Scaffold in the Femoral Head
Journal of the Korean Society for Precision Engineering
2022 .08
-
Tissue-Engineered Hydroxyapatite Bone Scaffold Impregnated with Osteoprogenitor Cells Promotes Bone Regeneration in Sheep Model
조직공학과 재생의학
2021 .01
-
Performance analysis of bone scaffolds with carbon nanotubes, barium titanate particles, hydroxyapatite and polycaprolactone
Biomaterials and Biomechanics in Bioengineering
2019 .01
-
Optimal Design and Biocompatibility of Bone Plate for Promoting Bone Tissue Regeneration via Ultrasound Stimulation
한국정밀공학회 학술발표대회 논문집
2017 .05
-
골 유도 재생을 위한 어골 함유 젤라틴-키토산 차폐막
폴리머
2022 .11
-
Development of Water-immiscible and Facile Binder for Effective Bone Grafting to Accelerate in vivo Bone Regeneration
한국생물공학회 학술대회
2015 .10
-
Bone Substitute Biomineral Complex Co-derived from Marine Biocalcification and Biosilicification
한국생물공학회 학술대회
2021 .04
-
Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice
Experimental and Molecular Medicine
2021 .04
-
Oxygen Carrier Containing Particles as a Tissue Engineering Scaffold for Improved Cell Viability and Bone Regeneration
한국고분자학회 학술대회 연구논문 초록집
2017 .10
-
The Effect of Heparin Immobilized Bacterial Cellulose Scaffolds and rhBMP-2 on Bone Regeneration in Rat Calvarial Defect Model
한국고분자학회 학술대회 연구논문 초록집
2017 .04
-
Functionalized Polycaprolactone-based 3D Printing Scaffold for Enhanced Bone Regeneration
한국고분자학회 학술대회 연구논문 초록집
2019 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0