지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 169 - 179 (11page)
- DOI
- 10.7783/KJMCS.2022.30.3.169
이용수
초록· 키워드
오류제보하기
Background: The safflower flower (Carthamus tinctorius) contains many bioactive substances and natural pigments. This study aimed to develop a safe and effective functional cosmetic material by comparing the antioxidant and anti-wrinkle effects of C. tinctorius flower ethanol extract (CTE) and hot water extract (CTW).
Methods and Results: First, the content of hydroxysafflor yellow A in CTE and CTW was determined. Subsequently, a cell-free system was used to examine the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of CTE and CTW. Furthermore, the effects of CTE and CTW on elastase and matrix metalloproteinase-1 (MMP-1) were determined through enzymatic analysis or real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in human dermal fibroblast (HDF) cells. The wound closure effect of CTW was also measured using the scratching assay in keratinocyte HaCaT cells. The DPPH scavenging activity of CTE was slightly higher than that of CTW. Regarding wrinkle formation, CTE unexpectedly increased MMP-1 and had no effect on elastase activity except at 1,000 ㎍/㎖ of CTE. In contrast, CTW inhibited both elastase activity and MMP-1 expression. CTW also showed a considerable increase in wound closure rate in the scratching assay.
Conclusions: In conclusion, CTW containing the natural pigment hydroxysafflor yellow A is an effective substance for wrinkle treatment and wound healing for skin aging.
Methods and Results: First, the content of hydroxysafflor yellow A in CTE and CTW was determined. Subsequently, a cell-free system was used to examine the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of CTE and CTW. Furthermore, the effects of CTE and CTW on elastase and matrix metalloproteinase-1 (MMP-1) were determined through enzymatic analysis or real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in human dermal fibroblast (HDF) cells. The wound closure effect of CTW was also measured using the scratching assay in keratinocyte HaCaT cells. The DPPH scavenging activity of CTE was slightly higher than that of CTW. Regarding wrinkle formation, CTE unexpectedly increased MMP-1 and had no effect on elastase activity except at 1,000 ㎍/㎖ of CTE. In contrast, CTW inhibited both elastase activity and MMP-1 expression. CTW also showed a considerable increase in wound closure rate in the scratching assay.
Conclusions: In conclusion, CTW containing the natural pigment hydroxysafflor yellow A is an effective substance for wrinkle treatment and wound healing for skin aging.
목차
ABSTRACT
서언
재료 및 방법
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REFERENCES
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