지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 706 - 716 (11page)
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초록· 키워드
오류제보하기
Background: Irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder, is characterized by chronic abdominal pain and bowel habit changes. Although diverse complicated etiologies are involved in its pathogenesis, a dysregulated gutebrain axis may be an important factor. Red ginseng (RG), a traditional herbal medicine, is proven to have anti-inflammatory effects and improve brain function; however, these effects have not been investigated in IBS.
Methods: Three-day intracolonic zymosan injections were used to induce post-infectious human IBS-like symptoms in mice. The animals were randomized to receive either phosphate-buffered saline (CG) or RG (30/100/300 mg/kg) for 10 days. Amitriptyline and sulfasalazine were used as positive controls. Macroscopic scoring was performed on day 4. Visceral pain and anxiety-like behaviors were assessed by colorectal distension and elevated plus maze and open field tests, respectively, on day 10. Nextgeneration sequencing of gut microbiota was performed, and biomarkers involved in gutebrain axis
responses were analyzed.
Results: Compared to CG, RG significantly decreased the macroscopic score, frequency of visceral pain, and anxiety-like behavior in the IBS mice. These effects were comparable to those after sulfasalazine and amitriptyline treatments. Moreover, RG significantly increased the proliferation of beneficial microbes, including Lactobacillus johnsonii, Lactobacillus reuteri, and Parabacteroides goldsteinii. RG significantly suppressed expression of IL-1b and c-fos in the gut and prefrontal cortex, respectively. Further, it restored the plasma levels of corticosterone to within the normal range, accompanied by an increase in adrenocorticotropic hormone.
Conclusion: RG may be a potential therapeutic option for the management of human IBS.
Methods: Three-day intracolonic zymosan injections were used to induce post-infectious human IBS-like symptoms in mice. The animals were randomized to receive either phosphate-buffered saline (CG) or RG (30/100/300 mg/kg) for 10 days. Amitriptyline and sulfasalazine were used as positive controls. Macroscopic scoring was performed on day 4. Visceral pain and anxiety-like behaviors were assessed by colorectal distension and elevated plus maze and open field tests, respectively, on day 10. Nextgeneration sequencing of gut microbiota was performed, and biomarkers involved in gutebrain axis
responses were analyzed.
Results: Compared to CG, RG significantly decreased the macroscopic score, frequency of visceral pain, and anxiety-like behavior in the IBS mice. These effects were comparable to those after sulfasalazine and amitriptyline treatments. Moreover, RG significantly increased the proliferation of beneficial microbes, including Lactobacillus johnsonii, Lactobacillus reuteri, and Parabacteroides goldsteinii. RG significantly suppressed expression of IL-1b and c-fos in the gut and prefrontal cortex, respectively. Further, it restored the plasma levels of corticosterone to within the normal range, accompanied by an increase in adrenocorticotropic hormone.
Conclusion: RG may be a potential therapeutic option for the management of human IBS.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (55)
참고문헌 신청
Halkjaer SI / 2017 / Can fecal microbiota transplantation cure irritable bowel syndrome / World J Gastroenterol 23:4112~4120
Carabotti M / 2015 / The gut-brain axis : interactions between enteric microbiota, central and enteric nervous systems / Ann Gastroenterol 28:203~209
Moloney RD / 2016 / Stress and the microbiota-gutbrain axis in visceral pain : relevance to irritable bowel syndrome / CNS Neurosci Ther 22:102~117
Enck P / 2016 / Irritable bowel syndrome / Nat Rev Dis Primers 2:16014
Banerjee A / 2017 / Anxiety and depression in irritable bowel syndrome / Indian J Psychol Med 39:741~745
Carabotti M / 2015 / The gut-brain axis : interactions between enteric microbiota, central and enteric nervous systems / Ann Gastroenterol 28:203~209
Moloney RD / 2016 / Stress and the microbiota-gutbrain axis in visceral pain : relevance to irritable bowel syndrome / CNS Neurosci Ther 22:102~117
Enck P / 2016 / Irritable bowel syndrome / Nat Rev Dis Primers 2:16014
Banerjee A / 2017 / Anxiety and depression in irritable bowel syndrome / Indian J Psychol Med 39:741~745
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