Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Yan Wan; Jing Wang; Jin-feng Xu; Fei Tang; Lu Chen; Yu-zhu Tan; Chao-long Rao; Hui Ao; Cheng Peng

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

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Type: Academic journal

Author: Yan Wan (Chengdu University of Traditional Chines Medicine) Jing Wang (Chengdu University of Traditional Chines Medicine) Jin-feng Xu (Chengdu University of Traditional Chines Medicine) Fei Tang (Chengdu University of Traditional Chines Medicine) Lu Chen (Chengdu University of Traditional Chines Medicine)

Journal: The Korean Society of Ginseng Journal of Ginseng Research Vol.45 No.6 KCI Candidated Journals SCIE

Published: 2021.11

Pages: 617 - 630 (14page)

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Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

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Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects. Therefore, developing new and effective drugs derived from natural nontoxic compounds for the treatment of chemotherapy-induced side effects is necessary. Experiments in vivo and in vitro indicate that Panax ginseng (PG) and its ginsenosides are undoubtedly non-toxic and effective options for the treatment of chemotherapy-induced side effects, such as nephrotoxicity, hepatotoxicity, cardiotoxicity, immunotoxicity, and hematopoietic inhibition. The mechanism focus on antioxidation, anti-inflammation, and anti-apoptosis, as well as the modulation of signaling pathways, such as nuclear factor erythroid-2 related factor 2 (Nrf2)/heme oxygenase-1 (HO-1), P62/keap1/Nrf2, c-jun Nterminal kinase (JNK)/P53/caspase 3, mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinases (ERK), AMP-activated protein kinase (AMPK)/mammalian target of rapamycin(mTOR), mitogen-activated protein kinase kinase 4 (MKK4)/JNK, and phosphatidylinositol 3-kinase(PI3K)/AKT. Since a systemic review of the effect and mechanism of PG and its ginsenosides on chemotherapy-induced side effects has not yet been published, we provide a comprehensive summarization with this aim and shed light on the future research of PG.

#Chemotherapy #Side effects #PG #Ginsenosides #Mechanism #Pharmacological effects

ABSTRACT
1. Introduction
2. Different types of PG and its ginsenosides
3. Effects of PG and its ginsenosides on chemotherapyinduced side effects
4. Discussion
5. Conclusion
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