지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.102 No.1
- 발행연도
- 2022.1
- 수록면
- 29 - 35 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: The etiology and pathogenesis of distal colitis (DC) are poorly understood. Activation of intestinal inflammatory response may lead to intestinal tissue necrosis. Antioxidant and anti-inflammatory agents are among the treatment options. Our study aimed to compare the protective effects of mesalazine and Ganoderma lucidum in acetic acid (AA)-induced colitis in rats.
Methods: Twenty-four rats were randomly grouped as colitis, mesalazine, G. lucidum, and combined (G. lucidum + mesalazine) groups. DC was induced by intrarectal administration of AA. Statistical comparisons were done by using parameters including colonic tissue IL-1, IL-6, TNF-α, and CRP levels. Histopathologic changes of the samples of colonic tissue were scored as mucosal damage score and inflammatory score. A P-value of <0.05 was considered significant.
Results: Intrarectal administration of AA leads to increased interleukin and CRP levels. High mucosal damage and inflammatory scores were noted in colitis group animals. Single mesalazine or G. lucidum treatment produced considerably decreased tissue interleukin and CRP levels. The lowest tissue interleukin and CRP levels were noted in the combined treatment group of animals. Mucosal damage and inflammatory scores were found to be significantly low in this group of animals.
Conclusion: The intrarectal administration of AA results in an activation of intestinal inflammation and severe mucosal damage in colonic tissue. Single use of mesalazine and G. lucidum treatment decreases the severity of intestinal inflammatory response and mucosal damage. The healing effects of the combined treatment of mesalazine and G. lucidum seem to be more effective than that of separate use in the treatment of DC.
Methods: Twenty-four rats were randomly grouped as colitis, mesalazine, G. lucidum, and combined (G. lucidum + mesalazine) groups. DC was induced by intrarectal administration of AA. Statistical comparisons were done by using parameters including colonic tissue IL-1, IL-6, TNF-α, and CRP levels. Histopathologic changes of the samples of colonic tissue were scored as mucosal damage score and inflammatory score. A P-value of <0.05 was considered significant.
Results: Intrarectal administration of AA leads to increased interleukin and CRP levels. High mucosal damage and inflammatory scores were noted in colitis group animals. Single mesalazine or G. lucidum treatment produced considerably decreased tissue interleukin and CRP levels. The lowest tissue interleukin and CRP levels were noted in the combined treatment group of animals. Mucosal damage and inflammatory scores were found to be significantly low in this group of animals.
Conclusion: The intrarectal administration of AA results in an activation of intestinal inflammation and severe mucosal damage in colonic tissue. Single use of mesalazine and G. lucidum treatment decreases the severity of intestinal inflammatory response and mucosal damage. The healing effects of the combined treatment of mesalazine and G. lucidum seem to be more effective than that of separate use in the treatment of DC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of efficacies of once-daily dose multimatrix mesalazine and multiple-dose mesalazine for the maintenance of remission in ulcerative colitis: a randomized, double-blind study
Intestinal research
2017 .01
-
Long lasting mesalazine-induced pancytopenia in a patient with ulcerative colitis
의생명과학
2019 .01
-
영지(Ganoderma lucidum)의 안전성에 대한 주제범위 문헌고찰
대한한방내과학회지
2024 .09
-
Comparison of efficacy of multimatrix mesalazine 4.8 g/ day once-daily with other high-dose mesalazine in active ulcerative colitis: a randomized, double-blind study
Intestinal research
2017 .01
-
영지버섯(Ganoderma lucidum)으로 부터 분리한 이차대사산물 및 이들의 항 염증 활성
생약학회지(Korean Journal of Pharmacognosy)
2019 .09
-
The Protective Effect of Ganoderma lucidum Extract in Ultraviolet B-Induced Human Dermal Fibroblasts and Skin Equivalent Models
Annals of Dermatology
2020 .01
-
Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients
Intestinal research
2019 .01
-
Protective effects of sigma 1 receptor agonist PRE084 on 2,4,6-trinitrobenzene sulfonic acid–induced experimental colitis in mice
Annals of Surgical Treatment and Research
2022 .09
-
헛개나무 추출물이 첨가된 영지버섯균사 추출물의 멜라닌 생성 억제효과
대한화장품학회지
2017 .01
-
Endoscopic Mucosal Healing as a Treatment Target in Ulcerative Colitis: Does It Have the Same Role in Asian Patients?
Gut and Liver
2021 .11
-
Polysaccharides from Panax ginseng promote intestinal epithelial cell migration through affecting the Ca2+ related regulators
Journal of Ginseng Research
2023 .01
-
Effect of Ganoderma Lucidum Pharmacopuncture on Chronic Liver Injury in Rats
대한침구의학회지
2015 .01
-
흰쥐에서 acetic acid로 유발된 궤양성 대장염에 대한 만년환의 효과
대한한방내과학회지
2024 .09
-
Cytokine Expression of Microscopic Colitis Including Interleukin-17
Gut and Liver
2015 .01
-
영지(靈芝)의 본초학적 고찰
한약정보연구회지
2020 .01
-
Corrigendum : Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients
Intestinal research
2020 .01
-
Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines
Journal of Ginseng Research
2023 .09
-
Amelioration of DSS-Induced Acute Colitis in Mice by Recombinant Monomeric Human Interleukin-22
Immune Network
2022 .06
-
The Improving Effect of Gastrodia elata Blume on DSS-induced Colitis in Mice
대한의생명과학회지
2018 .09
-
영지버섯추출물 및 에르고스테롤의 냉감 수용체 TRPM8 (Transient Receptor Potential Cation Channel Melastatin Subtype 8) 발현 유도 효과
대한화장품학회지
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0