지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 358 - 367 (10page)
이용수
초록· 키워드
오류제보하기
Background/Aims: This study compared the efficacy of once-daily administration of multimatrix mesalazine 2.4 g/day withmultiple-dose mesalazine for the maintenance of remission. Methods: In this multicenter, randomized, double-blind study,203 patients with ulcerative colitis in remission received multimatrix mesalazine 2.4 g/day once-daily or time-dependent (controlled-release) mesalazine 2.25 g/day 3 times-daily for 48 weeks. The primary efficacy endpoint was the proportion of patientswithout rectal bleeding. Results: The proportion of patients without rectal bleeding during the 48-week treatment period in theper protocol set was 84.8% (84/99) in the multimatrix mesalazine 2.4 g/day group and 78.0% (78/100) in the controlled-releasemesalazine 2.25 g/day group. The difference between the 2 treatment groups was 6.8% (two-sided 95% confidence interval,−3.9% to 17.6%). The noninferiority margin of −10% was met in the comparison of multimatrix mesalazine 2.4 g/day once-dailywith controlled-release mesalazine 2.25 g/day. Multimatrix mesalazine 2.4 g/day once-daily demonstrated consistent efficacyin all subgroups. There was no difference between the 2 treatment groups with regard to safety. Conclusions: A once-dailydose of 2 multimatrix mesalazine tablets (2.4 g) was not inferior to controlled-release mesalazine 2.25 g/day 3 times-daily inmaintaining absence of rectal bleeding in ulcerative colitis.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Miner P / 1995 / Safety and efficacy of controlled-release mesalamine for maintenance of remission in ulcerative colitis: Pentasa UC Maintenance Study Group / Dig Dis Sci 40:296~304
Ardizzone S / 1999 / Is maintenance therapy always necessary for patients with ulcerative colitis in remission? / Aliment Pharmacol Ther 13:373~379
Hanauer SB / 1996 / An oral preparation of mesalamine as long-term maintenance therapy for ulcerative colitis: a randomized, placebo-controlled trial / Ann Intern Med 124:204~211
Hawkey CJ / 1997 / A trial of zileuton versus mesalazine or placebo in the maintenance of remission of ulcerative colitis: the European Zileuton Study Group for Ulcerative Colitis / Gastroenterology 112:718~724
Feagan BG / 2012 / Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis / Cochrane Database Syst Rev 10:CD000544
Ardizzone S / 1999 / Is maintenance therapy always necessary for patients with ulcerative colitis in remission? / Aliment Pharmacol Ther 13:373~379
Hanauer SB / 1996 / An oral preparation of mesalamine as long-term maintenance therapy for ulcerative colitis: a randomized, placebo-controlled trial / Ann Intern Med 124:204~211
Hawkey CJ / 1997 / A trial of zileuton versus mesalazine or placebo in the maintenance of remission of ulcerative colitis: the European Zileuton Study Group for Ulcerative Colitis / Gastroenterology 112:718~724
Feagan BG / 2012 / Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis / Cochrane Database Syst Rev 10:CD000544
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of efficacy of multimatrix mesalazine 4.8 g/ day once-daily with other high-dose mesalazine in active ulcerative colitis: a randomized, double-blind study
Intestinal research
2017 .01
-
Long lasting mesalazine-induced pancytopenia in a patient with ulcerative colitis
의생명과학
2019 .01
-
Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients
Intestinal research
2019 .01
-
Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats
Annals of Surgical Treatment and Research
2022 .01
-
Corrigendum : Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients
Intestinal research
2020 .01
-
Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Pyoderma Gangrenosum of the Chest Wall in a Male Patient with Ulcerative Colitis
대한내과학회지
2021 .02
-
Drug-induced eosinophilic pneumonia in a patient with Crohn’s disease: diagnosis and treatment using fraction of exhaled nitric oxide
Intestinal research
2017 .01
-
Factors related to Quality of Life of Patients with Ulcerative Colitis
성인간호학회 학술대회
2015 .04
-
Ulcerative Colitis and Patient’s Quality of Life, Especially in Early Stage
Gut and Liver
2022 .05
-
5-[(3-Carboxy-4-hydroxyphenyl)diazenyl] nicotinic acid, an azo-linked mesalazine-nicotinic acid conjugate, is a colon-targeted mutual prodrug against dextran sulfate sodium-induced colitis in mice
Journal of Pharmaceutical Investigation
2021 .01
-
Is the Long-term Disease Course of Elderly-Onset Ulcerative Colitis Different from That of Non-Elderly-Onset Ulcerative Colitis?
Gut and Liver
2021 .09
-
Steroid-refractory extensive enteritis complicated by ulcerative colitis successfully treated with adalimumab
Intestinal research
2017 .01
-
Multimatrix distribution and bioaccumulation of legacy and emerging per- and polyfluoroalkyl substances (PFASs) in the environment of Korea
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
청소년궤양성 대장염 환자의 사상체질요법에 대한 증례보고
대한한방내과학회지
2017 .01
-
The impact of clinical experience on decision-making regarding the treatment and management of mild-to-moderate ulcerative colitis
Intestinal research
2023 .01
-
Current and Emerging Biologics for Ulcerative Colitis
Gut and Liver
2015 .01
-
Mitochondrial dysfunction of epithelial cell drives submucosal thickening through inflammatory fibroblasts in ulcerative colitis
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Lesson from Real-World Experience: Optimal Treatment with Anti-Tumor Necrosis Factor for Ulcerative Colitis
Gut and Liver
2021 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0