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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 235 - 241 (7page)
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This study aimed to explore the correlation between usual vitamin K intake and response to anticoagulant therapy among patients under warfarin therapy. We conducted a retrospective survey of patients (n = 50) on continuous warfarin therapy. Clinical information and laboratory parameters were sourced from medical records. Anticoagulant effect was evaluated by using the percent time in therapeutic range (TTR) and the coefficient of variation (CV) of International normalized ratio (INR). Dietary vitamin K intake was assessed using a semi-quantitative food frequency questionnaire that has been developed for the purpose of assessing dietary intake of vitamin K. A total of 50 patients aged between 21 and 87 years were included in the study. The mean vitamin K intake was 262.8 ± 165.2 μg/day. Study subjects were divided into tertiles according to their usual vitamin K intake. The proportion of men was significantly higher in second and third tertile than first tertile (p = 0.028). The mean percent TTR was 38.4 ± 28.4% and CV of INR was 31.8 ± 11.8%. Long-term warfarin therapy group (≥ 3 years) had a higher percentage of TTR as compared to the control group (< 3 years) (p = 0.046). No statistically significant correlation was found between usual vitamin K intake and percent TTR (p > 0.05). In conclusion, no significant association was observed between usual vitamin K intake and anticoagulant effects. Further studies are required to consider inter-individual variability of vitamin K intake. Development of assessment tools to measure inter-individual variability of vitamin K intake might be helpful.
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참고문헌 (33)
참고문헌 신청
Savelieva I / 2008 / Update on atrial fibrillation: part I / Clin Cardiol 31:55~62
Jeong Joon Hoon / 2005 / Prevalence of and Risk Factors for Atrial Fibrillation in Korean Adults Older than 40 Years / Journal of Korean Medical Science 20(1):26~30
Siguret V / 2008 / Warfarin therapy: influence of pharmacogenetic and environmental factors on the anticoagulant response to warfarin / Vitam Horm 78:247~264
Hirsh J / 1995 / Oral anticoagulants. Mechanism of action, clinical effectiveness, and optimal therapeutic range / Chest 108:231S~246S
Oake N / 2008 / Anticoagulation intensity and outcomes among patients prescribed oral anticoagulant therapy: a systematic review and meta-analysis / CMAJ 179:235~244
Jeong Joon Hoon / 2005 / Prevalence of and Risk Factors for Atrial Fibrillation in Korean Adults Older than 40 Years / Journal of Korean Medical Science 20(1):26~30
Siguret V / 2008 / Warfarin therapy: influence of pharmacogenetic and environmental factors on the anticoagulant response to warfarin / Vitam Horm 78:247~264
Hirsh J / 1995 / Oral anticoagulants. Mechanism of action, clinical effectiveness, and optimal therapeutic range / Chest 108:231S~246S
Oake N / 2008 / Anticoagulation intensity and outcomes among patients prescribed oral anticoagulant therapy: a systematic review and meta-analysis / CMAJ 179:235~244
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