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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 306 - 313 (8page)
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We investigated the effect of in vitro cultured Wnt3a-producing fibroblasts on positive bone balance and regeneration of the osteopenic skeleton. Thirty-six female Wistar rats (250–300 g, aged 12 weeks) were randomized into three groups: a control group (sham-operated), ovariectomy (OVX) group, and OVX with Wnt-cell injection (OVX with Wnt) group. Wnt3a-producing fibroblasts were injected into the lateral tail vein at 2 and 4 weeks after OVX. Both tibias were removed at 5, 6, 7, and 8 weeks after OVX, and pathological and micro- CT evaluations were performed. We also evaluated β-catenin expression by immunohistochemical staining. For bone metabolism detection, we evaluated the expression of bone alkaline phosphatase (BALP), osteocalcin, and C-telopeptide of collagen type I. Bone mineral density, trabecular bone volume, trabecular number, trabecular thickness were higher, while trabecular seperation was lower, in the OVX with Wnt group than in the OVX group. BALP and osteocalcin levels were significantly higher in the OVX with Wnt group compared to the control and OVX groups. β-catenin expression was significantly lower in the OVX group than in the other two groups. Based on these results, we hypothesized that Wnt3a-producing fibroblasts may be effective for the induction of bone formation.
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참고문헌 (21)
참고문헌 신청
Khosla S / 2005 / Pathophysiology of age-related bone loss and osteoporosis / Endocrinol Metab Clin North Am 34:1015~1030
Voskaridou E / 2004 / New insights into the pathophysiology and management of osteoporosis in patients with beta thalassaemia / Br J Haematol 127:127~139
Christenson RH / 1997 / Biochemical markers of bone metabolism : an overview / Clin Biochem 30:573~593
Kanis JA. / 1994 / Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report / Osteoporos Int 4:368~381
정제훈 / 2015 / Adipose Tissue-Derived Stem Cells in the Ovariectomy-Induced Postmenopausal Osteoporosis Rat Model / 조직공학과 재생의학 12(1):28~36
Voskaridou E / 2004 / New insights into the pathophysiology and management of osteoporosis in patients with beta thalassaemia / Br J Haematol 127:127~139
Christenson RH / 1997 / Biochemical markers of bone metabolism : an overview / Clin Biochem 30:573~593
Kanis JA. / 1994 / Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report / Osteoporos Int 4:368~381
정제훈 / 2015 / Adipose Tissue-Derived Stem Cells in the Ovariectomy-Induced Postmenopausal Osteoporosis Rat Model / 조직공학과 재생의학 12(1):28~36
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