지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 503 - 510 (8page)
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초록· 키워드
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BACKGROUND: Recruitment and homing cells into graft materials from host tissue is crucial for bone regeneration. METHODS: Highly porous, multi-level structural, hydroxyapatite bone void filler (HA-BVF) have been investigated to restore critical size bone defects. The aim was to investigate a feasibility of bone regeneration of synthetic HA-BVF compared to commercial xenograft (Bio-Oss). HA-BVF of 0.7 mm in average diameter was prepared via template coating method. Groups of animals (n = 6) were divided into two with normal (Sham) or induced osteoporotic conditions (Ovx). Subsequently, subdivided into three treated with HA-BVF as an experiment or Bio-Oss as a positive control or no treatment as a negative control (defect). The new bone formation was analyzed by micro-CT and histology. RESULTS: At 4 weeks post-surgery, new bone formation was initiated from all groups. At 8 weeks post-surgery, new bone formation in the HA-BVF groups was greater than Bio-Oss groups. Extraordinarily greater bone regeneration within the Ovx-HA group than Sham–Bio-Oss or Ovx–Bio-Oss group (p\0.05). CONCLUSION: This study suggests that the immediate wicking property of HA-BVF from host tissue activates a natural healing cascade without the addition of exogeneous factors or progenitor cells. HA-BVF may be an effective alternative for repairing bone defects under both normal and osteoporotic bone conditions.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Petrie Aronin CE / 2009 / Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds / J Biomed Mater Res A 89:632~641
Guzman R / 2014 / Chitosan scaffolds containing calcium phosphate salts and rhBMP-2: in vitro and in vivo testing for bone tissue regeneration / PLoS One 9:e87149
Jabbarzadeh E / 2018 / Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach / Proc Natl Acad Sci U S A 105:11099~11104
Cha JK / 2014 / Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs / J Clin Periodontol 41:86~93
Zhao J / 2009 / Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines / Bone 45:517~527
Guzman R / 2014 / Chitosan scaffolds containing calcium phosphate salts and rhBMP-2: in vitro and in vivo testing for bone tissue regeneration / PLoS One 9:e87149
Jabbarzadeh E / 2018 / Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach / Proc Natl Acad Sci U S A 105:11099~11104
Cha JK / 2014 / Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs / J Clin Periodontol 41:86~93
Zhao J / 2009 / Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines / Bone 45:517~527
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