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Objective: The purpose of this study was to examine 3 kinds of dentifrice contained such ingredients as CaCo3 and tocoperol citrate as brand A, silica; hydrogen carbonate sodium and pyro-phosphate sodium as brand B and silica, Megnolia extracts, carbon oxide dried exo and sodium fluoride and sodium carbonate as brand C. Methods: Fifty-one adults volunteers were participated in this clinical study, through the examination of gingival inflammation through photo taking of oral cavity by use of digital single-lens reflex (DSLR) camera, as well as the questionnaire after using the dentifrice. Results: Excessive smell from flavor was felt the most in group B users and group C was the next and the last in group A, otherwise there was no significant different between group A data and group C, in statistical (p<0.05). The comprehensive feeling for satisfaction on using dentifrice was the best in group C and the next in group A and the last in group B. Papillary marginal attached index as frontal area inflammation degree was the highest in group B and the relatively lower in group A and group C (p<0.05), but there was no significant different between in group A and in group C, statistically (p>0.05). Conclusion: It was recommended to use the natural anti-septic materials as Magnoia extracts such like as contained in group C dentifrice gradually instead of the use of the artificial conservatives or antiseptics in dentifrice for safety on health and reduction of irritation from those ingredients in dentifrice.

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