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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 341 - 350 (10page)
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons in the brain and spinal cord, resulting in paralysis of voluntary skeletal muscles and eventually death, usually within 2~3 years of symptom onset. The pathophysiology mechanism underlying ALS is not yet clearly understood. Moreover the available medication for treating ALS, riluzole, only modestly improves neurological symptoms and increases survival by a few months. Therefore, improved therapeutic strategies are urgently needed. In the present study, we investigated whether rosmarinic acid has a therapeutic potential to alleviate neurological deterioration in the G93A-SOD1 transgenic mouse model of ALS. Treatment of G93A-SOD1 transgenic mice with rosmarinic acid from 7 weeks of age at the dose of 400 mg/kg/day significantly extended survival, and relieved motor function deficits. Specifically, disease onset and symptom progression were delayed by more than one month. These symptomatic improvements were correlated with decreased oxidative stress and reduced neuronal loss in the ventral horns of G93A-SOD1 mice. These results support that rosmarinic acid is a potentially useful supplement for relieving ALS symptoms.
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등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Mulder DW / 1982 / Clinical limits of amyotrophic lateral sclerosis / Adv Neurol 36:15~22
Mitsumoto H / 1998 / Amyotrophic lateral sclerosis / Oxford University Press
Pasinelli P / 2000 / Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis / Proc Natl Acad Sci U S A 97:13901~13906
Boillée S / 2006 / Onset and progression in inherited ALS determined by motor neurons and microglia / Science 312:1389~1392
Ferraiuolo L / 2007 / Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS / J Neurosci 27:9201~9219
Mitsumoto H / 1998 / Amyotrophic lateral sclerosis / Oxford University Press
Pasinelli P / 2000 / Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis / Proc Natl Acad Sci U S A 97:13901~13906
Boillée S / 2006 / Onset and progression in inherited ALS determined by motor neurons and microglia / Science 312:1389~1392
Ferraiuolo L / 2007 / Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS / J Neurosci 27:9201~9219
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