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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 71 - 83 (13page)
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Artemisia princeps (AP) is a flowering perennial used as a traditional medicine and dietary supplement across East Asia. No study has yet assessed its effects on synaptic plasticity in hippocampus and much less in a model of ovarian hormone deficiency. We examined the influence of chronic oral AP ethanol extract treatment in ovariectomized rats on the induction of long-term depression in a representative synapse (CA3-CA1) of the hippocampus. Ovariectomized rats demonstrated lower trabecular mean bone mineral densities than sham, validating the establishment of pathology. Against this background of pathology, AP-treated ovariectomized rats exhibited attenuated long-term depression (LTD) in CA1 relative to water-treated controls as measured by increased field excitatory post-synaptic potentials (fEPSP) activation averages over the post-stimulation period. While pathological significance of long-term depression (LTD) in ovariectomized rats is conflicting, that AP treatment significantly affected its induction offers justification for further study of its influences on plasticity and its related disorders.
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참고문헌 (74)
참고문헌 신청
Faravelli C / 2013 / Gender differences in depression and anxiety: the role of age / Psychiatry Res 210:1301~1303
Jane Costello E / 2006 / Is there an epidemic of child or adolescent depression? / J Child Psychol Psychiatry 47:1263~1271
Munhoz TN / 2013 / Major depressive episode among Brazilian adults: a cross-sectional population-based study / J Affect Disord 150:401~407
Cole MG / 2003 / Risk factors for depression among elderly community subjects: a systematic review and meta-analysis / Am J Psychiatry 160:1147~1156
Zhang L / 2012 / The prevalence of depressive symptoms among the older in China: a metaanalysis / Int J Geriatr Psychiatry 27:900~906
Jane Costello E / 2006 / Is there an epidemic of child or adolescent depression? / J Child Psychol Psychiatry 47:1263~1271
Munhoz TN / 2013 / Major depressive episode among Brazilian adults: a cross-sectional population-based study / J Affect Disord 150:401~407
Cole MG / 2003 / Risk factors for depression among elderly community subjects: a systematic review and meta-analysis / Am J Psychiatry 160:1147~1156
Zhang L / 2012 / The prevalence of depressive symptoms among the older in China: a metaanalysis / Int J Geriatr Psychiatry 27:900~906
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