지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 356 - 375 (20page)
이용수
초록· 키워드
오류제보하기
Dexmedetomidine (DEX) has neuroprotective effects and its efficacy was determined in propofol-treated pups. Postnatal day (P) 7 rats were exposed to propofol and DEX to investigate the induced apoptosis-related gene expression. Furthermore, synaptic structural changes at the cellular level were observed by electron microscopy. Induction of hippocampal long-term potentiation (LTP) of P30 rats and long-lasting performance of spatial discrimination at P30 and P60 were evaluated. After a single propofol exposure to P7 rats, DEX pretreatment effectively rescued the profound apoptosis seen in hippocampal neurocytes, and strongly reversed the aberrant expression levels of Bcl2-like 1 (BCL2L1), matrix metallopeptidase 9 (MMP-9) and cleaved caspase 3 (CC3), and sharply enhanced synaptic plasticity. However, there were no significant differences in escape latency or crossing times in a probe test. This was accompanied by no obvious reduction in search strategies among the rat groups. No impairment of long-term learning and memory in P30 or P60 rats was detected when using a single dose propofol treatment during the most vulnerable period of brain development. DEX was shown to ameliorate the rodent developmental neurotoxicity caused by a single neonatal propofol challenge, by altering MMP-9, BCL2L1 and CC3 apoptotic signaling.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Backeljauw B / 2015 / Cognition and brain structure following early childhood surgery with anesthesia / Pediatrics 136:e1~e12
Liang X / 2017 / Effect of repeated neonatal sevoflurane exposure on the learning, memory and synaptic plasticity at juvenile and adult age / Am J Transl Res 9:4974~4983
Emad S. Osman / 2012 / In vivo effects of different anesthetic agents on apoptosis / Korean Journal of Anesthesiology 63(1):18~24
Yu D / 2013 / Repeated exposure to propofol potentiates neuroapoptosis and long-term behavioral deficits in neonatal rats / Neurosci Lett 534:41~46
Liu F / 2014 / Protective effect of acetyl-L-carnitine on propofol-induced toxicity in embryonic neural stem cells / Neurotoxicology 42:49~57
Liang X / 2017 / Effect of repeated neonatal sevoflurane exposure on the learning, memory and synaptic plasticity at juvenile and adult age / Am J Transl Res 9:4974~4983
Emad S. Osman / 2012 / In vivo effects of different anesthetic agents on apoptosis / Korean Journal of Anesthesiology 63(1):18~24
Yu D / 2013 / Repeated exposure to propofol potentiates neuroapoptosis and long-term behavioral deficits in neonatal rats / Neurosci Lett 534:41~46
Liu F / 2014 / Protective effect of acetyl-L-carnitine on propofol-induced toxicity in embryonic neural stem cells / Neurotoxicology 42:49~57
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Swimming Exercise and Nicotine Injection during Pregnancy on Spatial Memory Function and Synaptic Plasticity Neurotrophic Factor in the Hippocampus of Rat Pups
한국생활환경학회지
2016 .08
-
Large rat
International Digital Design Invitation Exhibition
2019 .12
-
Large rat
International Digital Design Invitation Exhibition
2024 .12
-
Large rat
한국콘텐츠학회 ICCC 논문집
2019 .12
-
Large rat
한국콘텐츠학회 ICCC 논문집
2024 .12
-
Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency
Experimental Neurobiology
2015 .01
-
β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats
Experimental Neurobiology
2021 .01
-
Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse
Experimental Neurobiology
2022 .12
-
Dehydroascorbic Acid Attenuates Ischemic Brain Edema and Neurotoxicity in Cerebral Ischemia: An in vivo Study
Experimental Neurobiology
2015 .01
-
Role of Medial Prefrontal Cortical Neurons and Oxytocin Modulation in the Establishment of Social Buffering
Experimental Neurobiology
2021 .01
-
Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
Experimental Neurobiology
2019 .01
-
강도별 유산소 운동이 비만 쥐 뇌 조직의 신경 가소성 관련 단백질 발현에 미치는 영향
한국생활환경학회지
2019 .12
-
운동이 골격근에서 Bcl-2, Bax 발현비율과 세포고사에 미치는 영향
한국웰니스학회지
2021 .02
-
Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity
Experimental Neurobiology
2022 .10
-
Physiological Roles of Monomeric Amyloid-β and Implications for Alzheimer’s Disease Therapeutics
Experimental Neurobiology
2022 .04
-
안드로겐 결핍 쥐에서 운동 중재에 따른 시냅스 단백질의 발현 양상 규명
한국생활환경학회지
2021 .10
-
Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos
Experimental Neurobiology
2020 .01
-
Mepelyzer : 서버 기반 다형상 모바일 앱에 대한 메소드 및 퍼미션 유사도 기반 악성앱 판별
한국융합학회논문지
2017 .01
-
Region-Specific Differences in the Apoe4-dependent Response to Focal Brain Injury
Experimental Neurobiology
2021 .08
-
Prenatal Exposure to High Cortisol Induces ADHD-like Behaviors with Delay in Spatial Cognitive Functions during the Post-weaning Period in Rats
Experimental Neurobiology
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0