지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 28 - 34 (7page)
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초록· 키워드
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Background: Pulmonary hypertension (PHT) is a recently recognized complicationof chronic kidney disease. In this study, we investigated the association betweenPHT, peripheral vascular calcifications (VCs), and major cardiovascular events.
Methods: In this retrospective study, we included 172 end-stage renal disease(ESRD) patients undergoing dialysis [hemodialysis (HD)¼84, peritoneal dialysis¼88]. PHT was defined as an estimated pulmonary artery systolic pressure437 mmHg using echocardiography. The Simple Vascular Calcification Score (SVCS)was measured using plain radiographic films of the hands and pelvis.
Results: The prevalence of PHT was significantly higher in HD patients (51.2% vs.
22.7%). Dialysis patients with PHT had a significantly higher prevalence of severeVCs (SVCSZ3). In multivariate analysis, the presence of severe VCs [odds ratio (OR),2.68], mitral valve disease (OR, 7.79), HD (OR, 3.35), and larger left atrial diameter(OR, 11.39) were independent risk factors for PHT. In addition to the presence ofanemia, severe VCs, or older age, the presence of PHT was an independent predictorof major cardiovascular events in ESRD patients.
Conclusion: The prevalence of PHT was higher in HD patients and was associatedwith higher rates of major cardiovascular events. Severe VCs are thought to be anindependent risk factor for predicting PHT in ESRD patients. Therefore, in dialysispatients with PHT, careful attention should be paid to the presence of VCs and theoccurrence of major cardiovascular events.
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참고문헌 (24)
참고문헌 신청
Simonneau G / 2013 / Updated clinical classification of pulmonary hypertension / J Am Coll Cardiol 62:D34~D41
Bolignano D / 2013 / Pulmonary hypertension in CKD / Am J Kidney Dis 61:612~622
Sise ME / 2013 / Pulmonary hypertension in patients with chronic and end-stage kidney disease / Kidney Int 84:682~692
Akmal M / 1995 / Excess PTH in CRF induces pulmonary calcification, pulmonary hypertension and right ventricular hypertrophy / Kidney Int 47:158~163
Amin M / 2003 / Pulmonary hypertension in patients with chronic renal failure : role of parathyroid hormone and pulmonary artery calcifications / Chest 124:2093~2097
Bolignano D / 2013 / Pulmonary hypertension in CKD / Am J Kidney Dis 61:612~622
Sise ME / 2013 / Pulmonary hypertension in patients with chronic and end-stage kidney disease / Kidney Int 84:682~692
Akmal M / 1995 / Excess PTH in CRF induces pulmonary calcification, pulmonary hypertension and right ventricular hypertrophy / Kidney Int 47:158~163
Amin M / 2003 / Pulmonary hypertension in patients with chronic renal failure : role of parathyroid hormone and pulmonary artery calcifications / Chest 124:2093~2097
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