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자료유형
학술저널
저자정보
이동현 (울산대학교) 이천우 (울산대학교) 권택민 (울산대학교) 유달산 (울산대학교) 정인갑 (울산대학교) 홍준혁 (울산대학교) 안한종 (울산대학교) 김청수 (울산대학교)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.56 No.8
발행연도
2015.1
수록면
565 - 571 (7page)

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Purpose: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelialneoplasia (HGPIN). Materials and Methods: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomyfor PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapyand were followed up for more than 1 year were included. The cohort was divided into two groups—patients with and withoutHGPIN—and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR. Results: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between thetwo groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN hada higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no otherpostoperative pathologic characteristics were significantly different between the two groups. There were no significant differencesin BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage(p<0.001) was associated with BCR. Conclusions: PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasionthan those without HGPIN. The presence of HGPIN is not an independent predictor of BCR.

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