지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제5호
- 발행연도
- 2017.1
- 수록면
- 471 - 481 (11page)
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초록· 키워드
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Background: Ductal adenocarcinoma (DAC) of the prostate is an uncommon histologic subtype whose prognostic factors and immunoprofile have not been fully defined. Methods: To define its prognostic factors and immunoprofile, the clinicopathological features, including biochemical recurrence (BCR), of 61 cases of DAC were analyzed. Immunohistochemistry was performed on tissue microarray constructs to assess the expression of prostate cancer-related and mammalian target of rapamycin (mTOR) signaling-related proteins. Results: During the median follow-up period of 19.3 months, BCR occurred in 26 cases (42.6%). DAC demonstrated a wide expression range of prostate cancer-related proteins, including nine cases (14.8%) that were totally negative for pan-cytokeratin (PanCK) immunostaining. The mTOR signaling-related proteins also showed diverse expression. On univariate analysis, BCR was associated with high preoperative serum levels of prostate-specific antigen (PSA), large tumor volume, predominant ductal component, high Gleason score (GS), comedo-necrosis, high tumor stage (pT), lymphovascular invasion, and positive surgical margin. High expressions of phospho-mTOR (p-mTOR) as well as low expressions of PSA, phospho-S6 ribosomal protein (pS6) and PanCK were associated with BCR. On multivariable analysis, GS, pT, and immunohistochemical expressions of PanCK and p-mTOR remained independent prognostic factors for BCR. Conclusions: These results suggest GS, pT, and immunohistochemical expressions of PanCK and p-mTOR as independent prognostic factors for BCR in DAC. Since DAC showed diverse expression of prostate cancer–related proteins, this should be recognized in interpreting the immunoprofile of DAC. The diverse expression of mTOR-related proteins implicates their potential utility as predictive markers for mTOR targeted therapy.
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참고문헌 (24)
참고문헌 신청
Bostwick DG / 1985 / Prostatic adenocarcinoma with endometrioid features: clinical, pathologic, and ultrastructural findings / Am J Surg Pathol 9 : 595 ~ 609
Copeland JN / 2002 / The morphologic spectrum of metastatic prostatic adenocarcinoma to the lung: special emphasis on histologic features overlapping with other pulmonary ne
Edge SB / 2010 / The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17 : 1471 ~ 1474
Epstein
Gong Y / 2006 / Metastatic ductal adenocarcinoma of the prostate: cytologic features and clinical findings / Am J Clin Pathol 126 : 302 ~ 309
Copeland JN / 2002 / The morphologic spectrum of metastatic prostatic adenocarcinoma to the lung: special emphasis on histologic features overlapping with other pulmonary ne
Edge SB / 2010 / The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17 : 1471 ~ 1474
Epstein
Gong Y / 2006 / Metastatic ductal adenocarcinoma of the prostate: cytologic features and clinical findings / Am J Clin Pathol 126 : 302 ~ 309
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