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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 451 - 460 (10page)
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초록· 키워드
오류제보하기
Diabetic nephropathy is a leading cause of end stage renal disease and its occurance is increasing worldwide. The most effective treatment strategy for the condition is intensive treatment to strictly control glycemia and blood pressure using renin-angiotensin system inhibitors. However, a fraction of patients still go on to reach end stage renal disease even under such intensive care. New therapeutic targets for diabetic nephropathy are, therefore, urgently needed. Autophagy is a major catabolic pathway by which mammalian cells degrade macromolecules and organelles to maintain intracellular homeostasis. The accumulation of damaged proteins and organelles is associated with the pathogenesis of diabetic nephropathy. Autophagy in the kidney is activated under some stress conditions, such as oxidative stress and hypoxia in proximal tubular cells, and occurs even under normal conditions in podocytes. These and other accumulating findings have led to a hypothesis that autophagy is involved in the pathogenesis of diabetic nephropathy. Here, we review recent findings underpinning this hypothesis and discuss the advantages of targeting autophagy for the treatment of diabetic nephropathy.
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등록된 정보가 없습니다.
참고문헌 (58)
참고문헌 신청
Abbate M / 2006 / How does proteinuria cause progressive renal damage? / J Am Soc Nephrol 17:2974~2984
Brownlee M / 2005 / The pathobiology of diabetic complications: a unifying mechanism / Diabetes 54:1615~1625
Dunlop M / 2000 / Aldose reductase and the role of the polyol pathway in diabetic nephropathy / Kidney Int Suppl 77:S3~S12
Forbes JM / 2003 / The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes / FASEB J 17:1762~1764
Ha H / 2008 / Role of reactive oxygen species in the pathogenesis of diabetic nephropathy / Diabetes Res Clin Pract 82(Suppl 1):S42~S45
Brownlee M / 2005 / The pathobiology of diabetic complications: a unifying mechanism / Diabetes 54:1615~1625
Dunlop M / 2000 / Aldose reductase and the role of the polyol pathway in diabetic nephropathy / Kidney Int Suppl 77:S3~S12
Forbes JM / 2003 / The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes / FASEB J 17:1762~1764
Ha H / 2008 / Role of reactive oxygen species in the pathogenesis of diabetic nephropathy / Diabetes Res Clin Pract 82(Suppl 1):S42~S45
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