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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 183 - 191 (9page)
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초록· 키워드
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Although Niemann-Pick C1-Like 1 (NPC1L1)plays a key role in intestinal cholesterol absorption, regulatingcholesterol metabolism and maintaining cholesterolmetabolic homeostasis, the molecular mechanism ofNPC1L1 in lipid-metabolism disorders leading to liverdisease remains largely unknown. Previous studies haveshown that NPC1L1 is related with the development offatty liver. Therefore, we hypothesized that NPC1L1 playsan important role in lipid-metabolism disorders and liverdisease by affecting the transcription of certain genesinvolved in lipid synthesis. To further elucidate the functionof NPC1L1, especially in the liver, we used somaticcellnuclear transfer to establish transgenic pigs thatexpressed human NPC1L1 in their livers. We investigatedsuperoxide dismutase activities and the levels of free fattyacids and malondialdehyde, a biomarker of lipid peroxidation.
Superoxide dismutase activities significantlydecreased, and free fatty acid and malondialdehyde levelssignificantly increased in the NPC1L1 transgenic pigs,indicating that the overexpression of NPC1L1 in the liverresulted in severe lipid peroxidation. Our findings suggestthat NPC1L1 plays an important role in lipid-metabolismdisorders and liver disease.
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등록된 정보가 없습니다.
참고문헌 (65)
참고문헌 신청
Al-Rawi NH / 2011 / Oxidative stress, antioxidant status and lipid profile in the saliva of type 2 diabetics / Diab Vasc Dis Res 8:22~28
Altmann SW / 2004 / Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption / Science 303:1201~1204
Anzenbacherová E / 2003 / Minipig as a model for drug metabolism in man: comparison of in vitro and in vivo metabolism of propafenone / Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:155~159
Assady M / 2011 / Superoxide dismutase (SOD) enzyme activity assay in fasciola spp. parasites and liver tissue extract / Iran J Parasitol 6:17~22
Assy N / 2006 / Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease / World J Gastroenterol 12:4369~4376
Altmann SW / 2004 / Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption / Science 303:1201~1204
Anzenbacherová E / 2003 / Minipig as a model for drug metabolism in man: comparison of in vitro and in vivo metabolism of propafenone / Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:155~159
Assady M / 2011 / Superoxide dismutase (SOD) enzyme activity assay in fasciola spp. parasites and liver tissue extract / Iran J Parasitol 6:17~22
Assy N / 2006 / Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease / World J Gastroenterol 12:4369~4376
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