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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 41 - 47 (7page)
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초록· 키워드
오류제보하기
Objective: Epidural injection of hyaluronic acid may prevent adhesion formation after spine surgery, but the compounds used to stabilize hyaluronidase could interfere with its anti-adhesion effects. The present study was conducted as a clinical trial to evaluate the efficacy and safety of an experimental medical gel in preventing adhesion formation. Methods: This study was designed as a multicenter, randomized, double-blind, and comparative controlled clinical trial with an observation period of 6 weeks. Subjects were randomly assigned into two groups: group A with sodium hyaluronate + 1,4-butanediol diglycidyl ether (BDDE) and group B with sodium hyaluronate + sodium carboxymethylcellulose (CMC). Visual analogue scale (VAS) of back and leg pain and the Oswestry disability index (ODI) and scar score ratings were assessed after surgery. Results: Mean scar grade was 2.37±1.13 in group A and 2.75±0.97 in group B, a statistically significant difference (p=0.012). VAS of back and leg pain and ODI scores decreased significantly from baseline to 3 and 6 weeks postoperatively in both groups (p<0.001). However, VAS and ODI scores were not statistically different between groups A and B at baseline or at 3 and 6 weeks after operation (p>0.3). The number of adverse reactions related to the anti-adhesion gels was not statistically different (p=0.569), but subsequent analysis of nervous adverse reactions showed group B was superior with a statistically difference (p=0.027). Conclusion: Sodium hyaluronate with BDDE demonstrated similar anti-adhesion properties to sodium hyaluronate with CMC. But, care should be used to nervous adverse reactions by using sodium hyaluronate with BDDE.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Akeson WH. / 2005 / Topical high-molecular-weight hyaluronan and a roofing barrier sheet equally inhibit postlaminectomy fibrosis / Spine J 5:180~190
Asch HL. / 2002 / Prospective multiple outcomes study of outpatient lumbar microdiscectomy : should 75 to 80% success rates be the norm? / J Neurosurg 96:34~44
BenDebba M. / 1999 / Association between peridural scar and activity-related pain after lumbar discectomy / Neurol Res 21:S37~42
Benoist M. / 1980 / Postoperative lumbar epiduro-arachnoiditis. Diagnostic and therapeutic aspects / Spine 5:432~436
Burton CV. / 1981 / Causes of failure of surgery on the lumbar spine / Clin Orthop Relat Res 157:191~199
Asch HL. / 2002 / Prospective multiple outcomes study of outpatient lumbar microdiscectomy : should 75 to 80% success rates be the norm? / J Neurosurg 96:34~44
BenDebba M. / 1999 / Association between peridural scar and activity-related pain after lumbar discectomy / Neurol Res 21:S37~42
Benoist M. / 1980 / Postoperative lumbar epiduro-arachnoiditis. Diagnostic and therapeutic aspects / Spine 5:432~436
Burton CV. / 1981 / Causes of failure of surgery on the lumbar spine / Clin Orthop Relat Res 157:191~199
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