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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,471 - 1,475 (5page)
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초록· 키워드
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Rotavirus (RV) is one of the most important viral etiologic agents of acute gastroenteritis (AGE) in children. Although effective RV vaccines (RVVs) are now used worldwide, novel genotypes and outbreaks resulting from rare genotype combinations have emerged. This study documented RV genotypes in a Korean population of children with AGE 5 yr after the introduction of RVV and assessed potential genotype differences based on vaccination status or vaccine type. Children less than 5-yr-old diagnosed with AGE between October 2012 and September 2013 admitted to 9 medical institutions from 8 provinces in Korea were prospectively enrolled. Stool samples were tested for RV by enzyme immunoassay and genotyped by multiplex reverse-transcription polymerase chain reaction. In 346 patients, 114 (32.9%) were RV-positive. Among them, 87 (76.3%) patients were infected with RV alone. Eighty-six of 114 RV-positive stool samples were successfully genotyped, and their combinations of genotypes were G1P[8] (36, 41.9%), G2P[4] (12, 14.0%), and G3P[8] (6, 7.0%). RV was detected in 27.8% of patients in the vaccinated group and 39.8% in the unvaccinated group (P = 0.035). Vaccination history was available for 67 of 86 cases with successfully genotyped RV-positive stool samples; RotaTeq (20, 29.9%), Rotarix (7, 10.4%), unvaccinated (40, 59.7%). The incidence of RV AGE is lower in the RV-vaccinated group compared to the unvaccinated group with no evidence of substitution with unusual genotype combinations.
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참고문헌 (31)
참고문헌 신청
Lanata CF / 2013 / Global causes of diarrheal disease mortality in children <5 years of age: a systematic review / PLoS One 8:e72788
Hoa Tran TN / 2013 / Molecular epidemiology of noroviruses associated with acute sporadic gastroenteritis in children: global distribution of genogroups, genotypes and GII.4 variants / J Clin Virol 56:185~193
Linhares AC / 2008 / Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: arandomised, double-blind, placebo-controlled phase III study / Lancet 371:1181~1189
Ruiz-Palacios GM / 2006 / Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis / N Engl J Med 354:11~22
Vesikari T / 2006 / Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine / N Engl J Med 354:23~33
Hoa Tran TN / 2013 / Molecular epidemiology of noroviruses associated with acute sporadic gastroenteritis in children: global distribution of genogroups, genotypes and GII.4 variants / J Clin Virol 56:185~193
Linhares AC / 2008 / Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: arandomised, double-blind, placebo-controlled phase III study / Lancet 371:1181~1189
Ruiz-Palacios GM / 2006 / Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis / N Engl J Med 354:11~22
Vesikari T / 2006 / Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine / N Engl J Med 354:23~33
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