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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 181 - 189 (9page)
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Background: Rotaviruses are a major cause of pediatric gastroenteritis. The rotavirus P[6] genotype is the most prevalent genotype isolated from Korean neonates but has rarely been reported in other countries. Histo-blood group antigen (HBGA) is known to play an important role in rotavirus infection. We investigated the relationship between rotavirus genotype and HBGA-Lewis blood type in Korean children and explored the reasons for the predominance of rotavirus P[6] strain in Korean neonates. Methods: Blood and stool samples were collected from 16 rotavirus-infected patients. Rotavirus G (VP7) and P (VP4) genotyping was performed using reverse transcription-PCR and sequencing. Lewis antigen phenotypes (Lea/Leb) were tested, and HBGA-Lewis genotype was determined by sequencing the secretor (FUT2) and Lewis (FUT3) genes. Deduced amino acid sequences and three-dimensional structures of the VP8* portion of the rotavirus VP4 protein were analyzed. Results: All P[6] rotaviruses were isolated from neonates under one month of age, who were negative or weakly positive for the Leb antigen. However, 10 of the 11 non-P[6] rotaviruses were isolated from older children who were Leb antigen-positive. The VP8* amino acid sequences differed among P[6], P[4], and P[8] genotypes. Korean P[6] strains showed a unique VP8* sequence with amino acid substitutions, including Y169>L169, which differed from the sequences of P[6] strains from other countries. Conclusions: The predominance of the rotavirus P[6] genotype in Korean neonates may be related to the interaction between HBGA-Lewis antigen and the VP8* portion of the VP4 protein, and this information will be helpful in future neonatal vaccine development.
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참고문헌 (28)
참고문헌 신청
Desselberger U / 2014 / Rotaviruses / Virus Res 190:75~96
Rotavirus Classification Working Group: RCWG–Laboratory of Viral Metagenomics
THANVAN THAI / 2013 / Prevalence of rotavirus genotypes in South Korea in 1989–2009: implications for a nationwide rotavirus vaccine program / Clinical and Experimental Pediatrics 56(11):465~473
Kawai K / 2012 / Burden of rotavirus gastroenteritis and distribution of rotavirus strains in Asia: a systematic review / Vaccine 30:1244~1254
Kim JS / 2014 / Analysis of rotavirus genotypes in Korea during 2013: an increase in the G2P[4]genotype after the introduction of rotavirus vaccines / Vaccine 32:6396~6402
Rotavirus Classification Working Group: RCWG–Laboratory of Viral Metagenomics
THANVAN THAI / 2013 / Prevalence of rotavirus genotypes in South Korea in 1989–2009: implications for a nationwide rotavirus vaccine program / Clinical and Experimental Pediatrics 56(11):465~473
Kawai K / 2012 / Burden of rotavirus gastroenteritis and distribution of rotavirus strains in Asia: a systematic review / Vaccine 30:1244~1254
Kim JS / 2014 / Analysis of rotavirus genotypes in Korea during 2013: an increase in the G2P[4]genotype after the introduction of rotavirus vaccines / Vaccine 32:6396~6402
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