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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 866 - 870 (5page)
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초록· 키워드
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Orientia tsutsugamushi, a causative pathogen of Scrub typhus, is a gram-negative intracellular bacterium. Outer membrane vesicles (OMVs) are produced from the membrane of bacteria and play many roles related to the survival of the pathogen. However, there have been no reports confirming whether O. tsutsugamushi indeed produce OMVs. O. tsutsugamushi boryong was cultured in ECV-304 cells for the purification of OMVs. Western blot analysis and immunoenrichment using anti-O. tsutsugamushi monoclonal antibody and electron microscopy were employed for identification and characterization of OMVs. We confirm the presence of OMVs derived from O. tsutsugamushi, and also found that those OMVs contain a major surface antigen of 56-kDa protein and variant immunogenic antigens.
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참고문헌 (25)
참고문헌 신청
Tamura A / 1995 / Classification of Rickettsia tsutsugamushi in a new genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov / Int J Syst Bacteriol 45:589~591
정문현 / 2012 / Persistence of Orientia tsutsugamushi in Humans / Journal of Korean Medical Science 27(3):231~235
Seong SY / 2001 / Orientia tsutsugamushi infection : overview and immune responses / Microbes Infect 3:11~21
Korean Centers for Diseases Control and Prevention / 2014 / Current status of selected infectious diseases / Public Health Wkly Rep 27:585~591
Collins BS / 2011 / Gram-negative outer membrane vesicles in vaccine development / Discov Med 12:7~15
정문현 / 2012 / Persistence of Orientia tsutsugamushi in Humans / Journal of Korean Medical Science 27(3):231~235
Seong SY / 2001 / Orientia tsutsugamushi infection : overview and immune responses / Microbes Infect 3:11~21
Korean Centers for Diseases Control and Prevention / 2014 / Current status of selected infectious diseases / Public Health Wkly Rep 27:585~591
Collins BS / 2011 / Gram-negative outer membrane vesicles in vaccine development / Discov Med 12:7~15
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