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논문 기본 정보

자료유형
학술저널
저자정보
Jong-Hun Ha (Gyeongsang National University School of Medicine) Dong-Hae Lee (Gyeongsang National University School of Medicine) Jin-Sik Park (Gyeongsang National University School of Medicine) Oh Hyun Cho (Gyeongsang National University School of Medicine) Dong-Hoon Kim (Gyeongsang National University School of Medicine) Na-Young Ha (Seoul National University College of Medicine) Nam-Hyuck Cho (Seoul National University College of Medicine) Kyu Jam Hwang (Korea Center for Disease Control and Prevention) Yong-Gon Cho (Chonbuk National University Medical School) Hye-Soo Lee (Chonbuk National University Medical School) Won Kil Lee (Kyungpook National University School of Medicine) Yoo Chul Lee (Kyungpook National University School of Medicine) Myung-Je Cho (Gyeongsang National University School of Medicine) Woo-Kon Lee (Gyeongsang National University School of Medicine) Min-Kyoung Shin (Gyeongsang National University School of Medicine)
저널정보
대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY JOURNAL OF BACTERIOLOGY AND VIROLOGY Vol.46 No.4
발행연도
2016.12
수록면
275 - 282 (8page)

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초록· 키워드

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Orientia tsutsugamushi (O. tsutsugamushi), which is endemic to an Asia-Pacific region, has increased its incidence and caused annually around 10 thousand patients infected with scrub typhus in Korea in the past several years. In the present study, we isolated 44 O. tsutsugamushi from the patients with febrile illness accompanied with or without an eschar in Gyeongsangnam-do, Korea. These isolates were characterized by genetic analysis of the major outer membrane protein, the 56-kDa type-specific antigen (tsa56), which is unique to O. tsutsugamushi. Two types of sequences of tsa56, designated by JJ1 and JJ2, were determined from 37 and 7 isolates of the 44 isolates, respectively. JJ1 and JJ2 showed 74.7~90.8% identity in nucleotide sequence and 66.1~90.5% identity in amino acid sequence with 33 reference strains except for Boryong and Kuroki. JJ1 and JJ2 had 100 and 99.9% nucleotide identity to Boryong strain, and 99.9 and 99.8 % to Kuroki, which has been known to be similar to Boryong, respectively. In addition, they showed 77.9~ 81.4% nucleotide identity with the cluster of Gilliam-related genotypes, whereas they showed higher nucleotide identity (89.6~90.8%) with the cluster of Karp-related genotypes. To our knowledge, this is the first report to isolate O. tsutsugamushi and characterize their genotype as the Boryong in Jinju and West Gyeongsangnam-do, Korea, even though it has been reported that the Boryong was the predominant genotype in isolates from chiggers, domestic rodents, and patients in the southern part of Korea. Furthermore, our isolates could be useful source to study on the pathophysiology and epidemiology of scrub typhus in Korea.

목차

INTRODUCTION
MATERIALS & METHODS
RESULTS & DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2017-475-001976785