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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 860 - 865 (6page)
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초록· 키워드
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We evaluated the association of the APOE polymorphism with serum C-reactive protein levels and white blood cell count in two large population-based studies in Korean. The datasets included the Dong-gu study (n = 8,893) and the Namwon Study (n = 10,032). APOE genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. Multivariable linear regression analysis was performed to evaluate the relationship of APOE genotypes with C-reactive protein levels and white blood cell count with adjustments for age, sex, body mass index, smoking, diabetes, hypertension, and serum lipids. In the multivariate model, carriers of E3E4 or E4E4 genotype had significantly lower C-reactive protein levels compared with carriers of E3E3 genotype group (0.50 mg/L vs. 0.67 mg/L; 0.37 mg/L vs. 0.67 mg/L, respectively, for the Dong-gu Study and 0.47 mg/L vs. 0.66 mg/L; 0.45 mg/L vs. 0.66 mg/L, respectively, for the Namwon Study). However, there was no difference in white blood cell count among APOE genotypes. We found that the APOE E4 allele is associated with lower C-reactive protein levels, but not white blood cell count. Our results suggest that APOE genotype may influence C-reactive protein levels through non-inflammatory pathway.
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등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Pepys MB / 2003 / C-reactive protein : a critical update / J Clin Invest 111:1805~1812
Kaptoge S / 2010 / C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis / Lancet 375:132~140
Danesh J / 2004 / C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease / N Engl J Med 350:1387~1397
Pankow JS / 2001 / Familial and genetic determinants of systemic markers of inflammation : the NHLBI family heart study / Atherosclerosis 154:681~689
Kannel WB / 1992 / White blood cell count and cardiovascular disease. Insights from the Framingham Study / JAMA 267:1253~1256
Kaptoge S / 2010 / C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis / Lancet 375:132~140
Danesh J / 2004 / C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease / N Engl J Med 350:1387~1397
Pankow JS / 2001 / Familial and genetic determinants of systemic markers of inflammation : the NHLBI family heart study / Atherosclerosis 154:681~689
Kannel WB / 1992 / White blood cell count and cardiovascular disease. Insights from the Framingham Study / JAMA 267:1253~1256
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