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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,006 - 1,012 (7page)
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초록· 키워드
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Objective The correlation among the thyroid-related hormones, Apolipoprotein E ε4 (APOE ε4) and cognitive function has been reported despite controversial results. This study was designed to investigate this correlation among cognitively-normal elderly dwellers.Methods This study assessed 507 cognitively normal individuals aged over 60 who underwent comprehensive hematological and neuropsychological assessments including the quantification of serum free thyroxine and thyroid stimulating hormone (TSH) as well as the Korean version of the Consortium Establish a Registry for Alzheimer’s disease. The Korean version of Geriatric Depression Scale was also employed to evaluate the severity of depression. Age, gender, education, and the presence of APOE ε4 were taken into account as covariates.Results There was a significant positive association between verbal fluency test (VFT), Word List Memory Test (WLMT), and Word List Recall Test (WLRT) score and serum TSH levels (p=0.007, 0.031, and 0.023 respectively). The further analysis adding the interaction between APOE ε4 and TSH level, however, revealed only VFT score was significantly influenced by this interaction (p=0.026).Conclusion Lower serum TSH levels had impacts on both semantic memory (VFT) and episodic memory (WLMT, WLRT) among cognitively-normal elderly, whereas the interaction of TSH and APOE ε4 influenced only the task of semantic memory (VFT) in this group.
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참고문헌 (40)
참고문헌 신청
Rasmussen J / 2019 / Alzheimer’s disease-Why we need early diagnosis / Degener Neurol Neuromuscul Dis 9:123~130
Dubois B / 2009 / Early detection of Alzheimer’s disease : new diagnostic criteria / Dialogues Clin Neurosci 11:135~139
Yiannopoulou KG / 2013 / Current and future treatments for Alzheimer’s disease / Ther Adv Neurol Disord 6:19~33
Galimberti D / 2011 / Disease-modifying treatments for Alzheimer’s disease / Ther Adv Neurol Disord 4:203~216
Breteler MM / 1991 / Medical history and the risk of Alzheimer’s disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group / Int J Epidemiol 20(Suppl 2):S36~S42
Dubois B / 2009 / Early detection of Alzheimer’s disease : new diagnostic criteria / Dialogues Clin Neurosci 11:135~139
Yiannopoulou KG / 2013 / Current and future treatments for Alzheimer’s disease / Ther Adv Neurol Disord 6:19~33
Galimberti D / 2011 / Disease-modifying treatments for Alzheimer’s disease / Ther Adv Neurol Disord 4:203~216
Breteler MM / 1991 / Medical history and the risk of Alzheimer’s disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group / Int J Epidemiol 20(Suppl 2):S36~S42
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