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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 816 - 822 (7page)
이용수
초록· 키워드
오류제보하기
Colloidal particle size is an important characteristic that allows mapping sentinel nodes in lymphoscintigraphy. This investigation aimed to introduce different ways of making a 99mTc-tin colloid with a size of tens of nanometers. All agents, tin fluoride, sodium fluoride, poloxamer-188, and polyvinylpyrrolidone (PVP), were mixed and labeled with 99mTc. Either phosphate or sodium bicarbonate buffers were used to adjust the pH levels. When the buffers were added, the size of the colloids increased. However, as the PVP continued to increase, the size of the colloids was controlled to within tens of nanometers. In all samples, phosphate buffer added PVP (30 mg) stabilized tin colloid (99mTc-PPTC-30) and sodium bicarbonate solution added PVP (50 mg) stabilized tin colloid (99mTc-BPTC-50) were chosen for in vitro and in vivo studies. 99mTc-BPTC-50 (< 20 nm) was primarily located in bone marrow and was then secreted through the kidneys, and 99mTc-PPTC-30 (> 100 nm) mainly accumulated in the liver. When a rabbit was given a toe injection, the node uptake of 99mTc-PPTC-30 decreased over time, while 99mTc-BPTC-50 increased. Therefore, 99mTc- BPTC-50 could be a good candidate radiopharmaceutical for sentinel node detection. The significance of this study is that nano-sized tin colloid can be made very easily and quickly by PVP.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Giuliano AE / 1995 / Improved axillary staging of breast cancer with sentinel lymphadenectomy / Ann Surg 222:394~399
나창주 / 2015 / The Clinical Value of Hybrid Sentinel Lymphoscintigraphy to Predict Metastatic Sentinel Lymph Nodes in Breast Cancer / Nuclear Medicine and Molecular Imaging 49(1):26~32
Morton DL / 1999 / Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: a multicenter trial. Multicenter Selective Lymphadenectomy Trial Group / Ann Surg 230:453~463
Nune SK / 2011 / Advances in lymphatic imaging and drug delivery / Adv Drug Deliv Rev 63:876~885
Boolbol SK / 2001 / Intradermal isotope injection : a highly accurate method of lymphatic mapping in breast carcinoma / Ann Surg Oncol 8:20~24
나창주 / 2015 / The Clinical Value of Hybrid Sentinel Lymphoscintigraphy to Predict Metastatic Sentinel Lymph Nodes in Breast Cancer / Nuclear Medicine and Molecular Imaging 49(1):26~32
Morton DL / 1999 / Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: a multicenter trial. Multicenter Selective Lymphadenectomy Trial Group / Ann Surg 230:453~463
Nune SK / 2011 / Advances in lymphatic imaging and drug delivery / Adv Drug Deliv Rev 63:876~885
Boolbol SK / 2001 / Intradermal isotope injection : a highly accurate method of lymphatic mapping in breast carcinoma / Ann Surg Oncol 8:20~24
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