Significance of Hormone Receptor Status in Comparison of 18F -FDG-PET/CT and 99mTc-MDP Bone Scintigraphy for Evaluating Bone Metastases in Patients with Breast Cancer: Single Center Experience

Teke, Fatma; Teke, Memik; Inal, Ali; Kaplan, Muhammed Ali; Kucukoner, Mehmet; Aksu, Ramazan; Urakci, Zuhat; Tasdemir, Bekir; Isikdogan, Abdurrahman

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자료유형: 학술저널

저자정보: Teke, Fatma (Department of Radiation Oncology, Medical School, Dicle University) Teke, Memik (Department of Radiology, Medical School, Dicle University) Inal, Ali (Department of Radiation Oncology, Medical School, Dicle University) Kaplan, Muhammed Ali (Department of Radiation Oncology, Medical School, Dicle University) Kucukoner, Mehmet (Department of Radiation Oncology, Medical School, Dicle University) Aksu, Ramazan (Department of Radiation Oncology, Diyarbakir Training and Research Hospital) Urakci, Zuhat (Department of Radiation Oncology, Medical School, Dicle University) Tasdemir, Bekir (Department of Nuclear Medicine, Medical School, Dicle University) Isikdogan, Abdurrahman (Department of Radiation Oncology, Medical School, Dicle University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제1호

발행연도: 2015.1

수록면: 387 - 391 (5page)

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Background: Fluorine-18 deoxyglucose positron emission tomography computed tomography (18F-FDG-PET/CT) and bone scintigraphy (BS) are widely used for the detection of bone involvement. The optimal imaging modality for the detection of bone metastases in hormone receptor positive (+) and negative (-) groups of breast cancer remains ambiguous. Materials and Methods: Sixty-two patients with breast cancer, who had undergone both 18F-FDG-PET/CT and BS, being eventually diagnosed as having bone metastases, were enrolled in this study. Results: 18F-FDG-PET/CT had higher sensitivity and specificity than BS. Our data showed that 18F-FDGPET/CT had a sensitivity of 93.4% and a specificity of 99.4%, whiel for BS they were 84.5%, and 89.6% in the diagnosis of bone metastases. ${\kappa}$ statistics were calculated for 18F-FDGPET/CT and BS. The ${\kappa}$-value was 0.65 between 18F-FDG-PET/CT and BS in all patients. On the other hand, the ${\kappa}$-values were 0.70 in the hormone receptor (+) group, and 0.51 in hormone receptor (-) group. The ${\kappa}$-values suggested excellent agreement between all patient and hormone receptor (+) groups, while the ${\kappa}$-values suggested good agreement in the hormone receptor (-) group. Conclusions: The sensitivity and specificity for 18F-FDG-PET/CT were higher than BS in the screening of metastatic bone lesions in all patients. Similarly 18F-FDG-PET/CT had higher sensitivity and specificity in hormone receptor (+) and (-) groups.

#Breast neoplasms #radionuclide imaging #positron-emission tomography and computed tomography

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