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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 779 - 787 (9page)
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초록· 키워드
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We compared the predictive ability of the various neuroimaging tools and determined the most cost-effective, non-invasive Alzheimer’s disease (AD) prediction model in mild cognitive impairment (MCI) individuals. Thirty-two MCI subjects were evaluated at baseline with [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET), MRI, diffusion tensor imaging (DTI), and neuropsychological tests, and then followed up for 2 yr. After a follow up period, 12 MCI subjects converted to AD (MCIc) and 20 did not (MCInc). Of the voxel-based statistical comparisons of baseline neuroimaging data, the MCIc showed reduced cerebral glucose metabolism (CMgl) in the temporo-parietal, posterior cingulate, precuneus, and frontal regions, and gray matter (GM) density in multiple cortical areas including the frontal, temporal and parietal regions compared to the MCInc, whereas regional fractional anisotropy derived from DTI were not significantly different between the two groups. The MCIc also had lower Mini-Mental State Examination (MMSE) score than the MCInc. Through a series of model selection steps, the MMSE combined with CMgl model was selected as a final model (classification accuracy 93.8%). In conclusion, the combination of MMSE with regional CMgl measurement based on FDG-PET is probably the most efficient, non-invasive method to predict AD in MCI individuals after a two-year follow-up period.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Petersen RC / 2004 / Mild cognitive impairment as a diagnostic entity / J Intern Med 256:183~194
Dickerson BC / 2007 / Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment / Arch Gen Psychiatry 64:1443~1450
Lee DY / 2006 / Combination of clinical and neuropsychologic information as a better predictor of the progression to Alzheimer disease in questionable dementia individuals / Am J Geriatr Psychiatry 14:130~138
Aggarwal NT / 2005 / The apolipoprotein E epsilon4 allele and incident Alzheimer’s disease in persons with mild cognitive impairment / Neurocase 11:3~7
Parnetti L / 2012 / Performance of abeta1-40, abeta1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairment / J Alzheimers Dis 29:229~238
Dickerson BC / 2007 / Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment / Arch Gen Psychiatry 64:1443~1450
Lee DY / 2006 / Combination of clinical and neuropsychologic information as a better predictor of the progression to Alzheimer disease in questionable dementia individuals / Am J Geriatr Psychiatry 14:130~138
Aggarwal NT / 2005 / The apolipoprotein E epsilon4 allele and incident Alzheimer’s disease in persons with mild cognitive impairment / Neurocase 11:3~7
Parnetti L / 2012 / Performance of abeta1-40, abeta1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairment / J Alzheimers Dis 29:229~238
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