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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 167 - 172 (6page)
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Purpose: The aim of this study was to investigate the prognosis, patterns of failure, and prognostic factors for breast cancer patients with pathologically proven synchronous ipsilateral supraclavicular lymph node (ISCLN) metastases. Methods: We reviewed the records of breast cancer patients with pathologically proven ISCLN metastases. Local aggressive treatment was defined as treatment including surgery, axillary lymph node dissection (ALND), ISCLN excision, radiotherapy (RT), and chemotherapy. Results: A total of 111 patients were included. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 64.2% and 56.2%, respectively. On univariate analysis, RT, ALND, trastuzumab treatment, hormone receptor (HR) status, and local aggressive treatment were identified as significant factors for OS. The 5-year OS for 73 patients who received local aggressive treatment was superior to that of 38 patients who received nonaggressive treatment (70.9% vs. 49.3%, p=0.036). Multivariate analysis showed that RT, HR status, and trastuzumab were significant variables for the 5-year OS and DFS. Conclusion: Multimodality treatment with surgery, taxane-based chemotherapy, hormone therapy, and RT is strongly recommended for breast cancer patients with synchronous ISCLN metastases.
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참고문헌 (11)
참고문헌 신청
Debois JM / 1997 / The significance of a supraclavicular node metastasis in patients with breast cancer : a literature review / Strahlenther Onkol 173:1~12
Brito RA / 2001 / Long-term results of combined-modality therapy for locally advanced breast cancer with ipsilateral supraclavicular metastases: The University of Texas M.D. Anderson Cancer Center experience / J Clin Oncol 19:628~633
Singletary SE / 2002 / Revision of the American Joint Committee on Cancer staging system for breast cancer / J Clin Oncol 20:3628~3636
Olivotto IA / 2003 / Long-term survival of patients with supraclavicular metastases at diagnosis of breast cancer / J Clin Oncol 21:851~854
Huang EH / 2007 / Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosis / Int J Radiat Oncol Biol Phys 67:490~496
Brito RA / 2001 / Long-term results of combined-modality therapy for locally advanced breast cancer with ipsilateral supraclavicular metastases: The University of Texas M.D. Anderson Cancer Center experience / J Clin Oncol 19:628~633
Singletary SE / 2002 / Revision of the American Joint Committee on Cancer staging system for breast cancer / J Clin Oncol 20:3628~3636
Olivotto IA / 2003 / Long-term survival of patients with supraclavicular metastases at diagnosis of breast cancer / J Clin Oncol 21:851~854
Huang EH / 2007 / Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosis / Int J Radiat Oncol Biol Phys 67:490~496
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