지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.4
- 발행연도
- 2021.12
- 수록면
- 445 - 452 (8page)
이용수
이 논문의 연구 히스토리 (10)
2017
Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells
Gi Dae Kim
Preventive Nutrition and Food Science
2017.12
학술저널
Effects of Korean Red Ginseng Extract on Endothelial Proliferation and Angiogenesis through Activating the MAPK and PI3K/AKT/mTOR Signaling Pathway
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
Antofine, a Natural Phenanthroindolizidine Alkaloid, Suppresses Angiogenesis via Regulation of AKT/mTOR and AMPK Pathway in Endothelial Cells and Endothelial Progenitor Cells Derived from Mouse Embryonic Stem Cells
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
2016
Honokiol Inhibits Vascular Vessel Formation of Mouse Embryonic Stem Cell-derived Endothelial Cells via the Suppression of PECAM and MAPK/mTOR Signaling Pathway
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2016.10
학술대회자료
Hesperidin inhibits vascular formation by blocking the AKT/mTOR signaling pathways
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2016.10
학술대회자료
2014
Hesperetin Inhibits Vascular Formation by Suppressing of the PI3K/AKT, ERK, and p38 MAPK Signaling Pathways.
Gi Dae Kim
Preventive Nutrition and Food Science
2014.12
학술저널
Magnolol Inhibits Angiogenesis by Regulating ROS-mediated Apoptosis and the PI3K/AKT/mTOR Signaling Pathway in mES/EB-derived Endothelial-like Cells
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2014.10
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Colorectal carcinoma (CRC) is one of the most common and aggressive malignant carcinomas. There is a pressing need to develop naturally derived novel drugs with minimal side effects for treatment of CRC. In this study, we aimed to investigate the anticancer effects of harmine hydrochloride (HMH), a hydrophilic and stable substance that is easily absorbed by tissues and similar to harmine, and the underlying mechanism of action in human CRC HCT116 cells. HMH inhibited the growth, colony formation, and migration ability of HCT116 cells. Additionally, HMH induced G2 cell cycle arrest by reducing expression of p-cdc2, cdc2, and cyclin B1, proteins that regulate the G2/M phase, and expression of Rb, a protein that regulates cell proliferation, in a dose-dependent manner. HMH mediated apoptosis by downregulating expression of apoptotic proteins (such as caspase-3, caspase-9, and PARP) and the anti-apoptotic protein Bcl-2 and by inducing expression of Bax, a pro-apoptotic protein. Furthermore, HMH reduced the levels of p-ERK, p-PI3K, p-AKT, and p-mTOR in HCT116 cells, and significantly inhibited p-ERK and p-AKT expression in cells treated with of HMH and PD98059, an ERK inhibitor, or LY294002, an AKT inhibitor (P<0.05 and P<0.01). These results demonstrate the inhibitory effect of HMH on cell proliferation and migration through inducing apoptosis by inhibiting ERK and PI3K/AKT/mTOR signaling pathways, indicating its potential therapeutic applications in CRC.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
Arthur JS / 2013 / Mitogen-activated protein kinases in innate immunity / Nat Rev Immunol 13:679~692
Bahrami A / 2018 / Therapeutic potential of targeting PI3K/AKT pathway in treatment of colorectal cancer : rational and progress / J Cell Biochem 119:2460~2469
Brancho D / 2005 / Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades / Mol Cell Biol 25:3670~3681
Chen X / 2017 / Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer / Br J Pharmacol 174:1131~1146
Das Thakur M / 2014 / Molecular pathways : response and resistance to BRAF and MEK inhibitors in BRAF(V600E)tumors / Clin Cancer Res 20:1074~1080
Bahrami A / 2018 / Therapeutic potential of targeting PI3K/AKT pathway in treatment of colorectal cancer : rational and progress / J Cell Biochem 119:2460~2469
Brancho D / 2005 / Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades / Mol Cell Biol 25:3670~3681
Chen X / 2017 / Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer / Br J Pharmacol 174:1131~1146
Das Thakur M / 2014 / Molecular pathways : response and resistance to BRAF and MEK inhibitors in BRAF(V600E)tumors / Clin Cancer Res 20:1074~1080
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Assembly-driven Enhanced Anticancer Effect of Berberine by Sodium Guaiazulene Sulfonate
최여진
,
김용주
한국고분자학회 학술대회 연구논문 초록집
2024
.09
Induction of Apoptosis of DK-5-62, a Novel (-)-Catechin Derivative Through MAPKs Signaling Pathway in HCT116 Cells
Tae Eun Guon
,
Dong-Soo Shin
,
Ha Sook Chung
대한화학회지
2022
.08
HCT116 대장암세포에서 Akt/Mdm2 신호 경로 조절을 통한 영릉향 헥산 분액물(LFH)의 Apoptosis 유도 효과 확인
서지원
,
이효재
,
이창열
외 2명
KSBB Journal
2021
.12
YM155, specific survivin inhibitor, can enhance artesunate-induced cytotoxicity in HCT116 colon cancer cells
Eui Tae Kim
,
Dong-Guk Pa
,
k
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2020
.12
인체 대장암 세포주 HCT 116와 HT-29에서 아팝토시스 세포사멸과 자가소화작용의 이중유도에 의한 녹나무 에탄올 추출물의 mTOR 신호경로를 통한 항암효과
남건희
,
조경조
,
박예슬
외 5명
KSBB Journal
2019
.06
최근 본 자료
댓글(0)
0