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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.20 No.4
- 발행연도
- 2015.12
- 수록면
- 221 - 229 (9page)
이용수
이 논문의 연구 히스토리 (10)
2017
Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells
Gi Dae Kim
Preventive Nutrition and Food Science
2017.12
학술저널
Effects of Korean Red Ginseng Extract on Endothelial Proliferation and Angiogenesis through Activating the MAPK and PI3K/AKT/mTOR Signaling Pathway
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
Antofine, a Natural Phenanthroindolizidine Alkaloid, Suppresses Angiogenesis via Regulation of AKT/mTOR and AMPK Pathway in Endothelial Cells and Endothelial Progenitor Cells Derived from Mouse Embryonic Stem Cells
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
2016
Honokiol Inhibits Vascular Vessel Formation of Mouse Embryonic Stem Cell-derived Endothelial Cells via the Suppression of PECAM and MAPK/mTOR Signaling Pathway
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2016.10
학술대회자료
Hesperidin inhibits vascular formation by blocking the AKT/mTOR signaling pathways
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2016.10
학술대회자료
2014
Hesperetin Inhibits Vascular Formation by Suppressing of the PI3K/AKT, ERK, and p38 MAPK Signaling Pathways.
Gi Dae Kim
Preventive Nutrition and Food Science
2014.12
학술저널
Magnolol Inhibits Angiogenesis by Regulating ROS-mediated Apoptosis and the PI3K/AKT/mTOR Signaling Pathway in mES/EB-derived Endothelial-like Cells
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2014.10
학술대회자료
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초록· 키워드
오류제보하기
Hesperidin has been shown to possess a potential inhibitory effect on vascular formation in endothelial cells. However, the fundamental mechanism for the anti-angiogenic activity of hesperidin is not fully understood. In the present study, we evaluated whether hesperidin has anti-angiogenic effects in mouse embryonic stem cell (mES)-derived endothelial-like cells, and human umbilical vascular endothelial cells (HUVECs), and evaluated their mechanism via the AKT/mammalian target of rapamycin (mTOR) signaling pathway. The endothelial cells were treated with several doses of hesperidin (12.5, 25, 50, and 100 M) for 24 h. Cell viability and vascular formation were analyzed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and tube formation assay, respectively. Alteration of the AKT/mTOR signaling in vascular formation was analyzed by western blot. In addition, a mouse aortic ring assay was used to determine the effect of hesperidin on vascular formation. There were no differences between the viability of mES-derived endothelial-like cells and HUVECs after hesperidin treatment. However, hesperidin significantly inhibited cell migration and tube formation of HUVECs (P＜0.05) and suppressed sprouting of microvessels in the mouse aortic ring assay. Moreover, hesperidin suppressed the expression of AKT and mTOR in HUVECs. Taken together, these findings suggest that hesperidin inhibits vascular formation by blocking the AKT/mTOR signaling pathways.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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Hesperidin inhibits vascular formation by blocking the AKT/mTOR signaling pathways
한국식품영양과학회 학술대회발표집
2016 .10
-
Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells
Preventive Nutrition and Food Science
2017 .12
-
Enhancement of Intestinal Barrier Function by Hesperidin through AMPK and Tight Junction-related Genes in Caco-2 Cell Monolayers
한국식품영양과학회 학술대회발표집
2021 .10
-
Honokiol Inhibits Vascular Vessel Formation of Mouse Embryonic Stem Cell-derived Endothelial Cells via the Suppression of PECAM and MAPK/mTOR Signaling Pathway
한국식품영양과학회 학술대회발표집
2016 .10
-
Effect of hesperidin on epithelial permeability in Caco-2 cell monolayers
한국식품영양과학회 학술대회발표집
2018 .10
-
Myricetin Inhibits Angiogenesis by Regulating ROS-Mediated Apoptosis and the PI3K/AKT/mTOR Signaling Pathway in Endothelial Cells.
한국식품영양과학회 학술대회발표집
2017 .10
-
Effects of Korean Red Ginseng Extract on Endothelial Proliferation and Angiogenesis through Activating the MAPK and PI3K/AKT/mTOR Signaling Pathway
한국식품영양과학회 학술대회발표집
2017 .10
-
Dioscin decreases breast cancer stem cell proliferation via cell cycle arrest by modulating p38 MAPK and AKT/mTOR signaling pathways
한국식품영양과학회 학술대회발표집
2022 .10
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Kaempferol Inhibits Angiogenesis through the Suppression of HIF-1α and VEGFR2 Expression via ERK/p38 MAPK-Dependent and PI3K/AKT/mTOR Signaling Pathways in Endothelial Cells.
한국식품영양과학회 학술대회발표집
2017 .10
-
AGS 위암세포주에서 Akt/mTOR 신호경로를 통한 영릉향 부탄올 분획물에서의 Apoptosis 유도 효과
한국식품영양과학회지
2022 .03
-
Enhancement of Intestinal Epithelial Permeability by Hesperidin through Tight Junction-related proteins in Caco-2 Cell Monolayers
한국식품영양과학회 학술대회발표집
2020 .10
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Hesperidin Prevents Sarcopenia through the Regulaltion of Inflammaging in 22-26-Month-Old C57BL/6J Mice
한국식품영양과학회 학술대회발표집
2023 .10
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Improvement Effect of Hesperidin on Intestinal Barrier in Radiation-induced Intestinal Barrier Dysfunction Caco-2 cells
한국식품영양과학회 학술대회발표집
2022 .10
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Effect of fermented soybean extract and collagen complex on muscle growth through PI3K/Akt/mTOR pathway in C2C12 myoblasts
한국식품영양과학회 학술대회발표집
2023 .10
-
Antofine, a Natural Phenanthroindolizidine Alkaloid, Suppresses Angiogenesis via Regulation of AKT/mTOR and AMPK Pathway in Endothelial Cells and Endothelial Progenitor Cells Derived from Mouse Embryonic Stem Cells
한국식품영양과학회 학술대회발표집
2017 .10
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HepG2 간암세포에서 미토콘드리아 경로를 통한 개똥쑥 추출물의 Apoptosis 유도 효과
한국식품영양과학회지
2016 .12
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Neuroprotective Effects of Hesperidin and its Aglycone Hesperetin as β-Secretase (BACE1) Inhibitors
한국식품영양과학회 학술대회발표집
2016 .10
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Harmine Hydrochloride induces G2/M arrest in MDA-MB-231 and MCF-7 human breast cancer cells by regulating the PI3K/AKT/mTOR signaling pathway
한국식품영양과학회 학술대회발표집
2020 .10
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Dendropanax Morbifera induced G0/G1 arrest and apoptosis in SK-Hep1 human hepatoma cancer cells by modulating the PI3K/AKT/mTOR signaling pathways
한국식품영양과학회 학술대회발표집
2020 .10
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Apoptosic Effects of Extracts from Cinnamomum camphora through Regulating AMPK/Akt/mTOR Signaling Pathways in HCT116 Colon Cancer Cells
한국식품영양과학회 학술대회발표집
2016 .10
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UCI(KEPA) : I410-ECN-0101-2016-594-002321440