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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 114 - 119 (6page)
- DOI
- 10.7841/ksbbj.2019.34.2.114
이용수
초록· 키워드
오류제보하기
Cinnamomum camphora is known as a tree that has been used in traditional medicine and food. However, its biological activities in cancer have not yet been clearly investigated. In this study, we investigate the anti-cancer effects of ethanol extract of Cinnamomum camphora on two kinds of human colon cancer cell lines (HCT 116 and HT-29). In previous study, about 50% of cancer cells have p53 mutations. Therefore, two kinds of cancer cells with different p53 gene mutation status are able to verify the effects of cancer more accurately. it is conducted several experiments to prove the effects of anti-cancer through apoptosis and autophagy. It is confirmed the anti-proliferative activity of Cinnamomum camphora ethanol extract through WST-1 assay. Cancer cell migration rate is detected by cell invasion assay and scratched wound healing assay. Also, the expression of apoptosis and autophagy related proteins are assessed by western blot. Our data reveal that Cinnamomum camphora ethanol extract inhibits the cancer cell growth of both p53 gene wild type HCT 116 human colon cancer cells and p53 gene mutation type HT-29 human colon cancer cells. Moreover, it confirms that CCD841 Human colon normal cells are not affected by Cinnamomum camphora ethanol extract. Cinnamomum camphora ethanol extract regulated expression of apoptotic and autophagic proteins in both cancer cells. Then, it is demonstrated that apoptosis and autophagy are induced through the mTOR pathway when treated with rapamycin (mTOR inhibitor). Taken together, these results show that Cinnamomum camphora ethanol extract has considerable potential as chemotherapeutic substance.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHOD
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (11)
참고문헌 신청
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박예슬 / 2018 / AGS위암세포에서 AMPK/Akt/GSK-3β 신호경로를 통한 삼채추출물의 항암효과 / KSBB Journal 33(4):293~298
LEE, H. J. / 2006 / In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts / J. Ethnopharmacol 103:208~216
이지선 / 2017 / 대장암 검진 행동 촉진을 위한 메시지 전략 / 한국콘텐츠학회 논문지 17(12):357~367
Amable, L. / 2016 / Cisplatin resistance and opportunities for precision medicine / Pharmacol. Res 106:27~36
박예슬 / 2018 / AGS위암세포에서 AMPK/Akt/GSK-3β 신호경로를 통한 삼채추출물의 항암효과 / KSBB Journal 33(4):293~298
LEE, H. J. / 2006 / In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts / J. Ethnopharmacol 103:208~216
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UCI(KEPA) : I410-ECN-0101-2019-470-000905147