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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 229 - 240 (12page)
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초록· 키워드
오류제보하기
Blood glucose homeostasis is well maintained by coordinated control of various hormones including insulin and glucagon as well as cytokines under normal conditions. However, chronic exposure to diabetic environment with high fat/high sugar diets and physical/ mental stress can cause hyperglycemia, one of main characteristics of insulin resistance, metabolic syndrome, and diabetes. Hyperglycemia impairs organogenesis and induces organ abnormalities such as cardiac defect in utero . It is a risk factor for the development of metabolic diseases in adults. Resulting glucotoxicity affects peripheral tissues and vessels, causing pathological complications including diabetic neuropathy, nephropathy, vessel damage, and cardiovascular diseases. Moreover, chronic exposure to hyperglycemia can deteriorate cognitive function and other aspects of mental health. Recent reports have demonstrated that hyperglycemia is closely related to the development of cognitive impairment and dementia, suggesting that there may be a cause-effect relationship between hyperglycemia and dementia. With increasing interests in aging-related diseases and mental health, diabetes-related cognitive impairment is attracting great attention. It has been speculated that glucotoxicity can result in structural damage and functional impairment of brain cells and nerves, hemorrhage of cerebral blood vessel, and increased accumulation of amyloid beta. These are potential mechanisms underlying diabetes-related dementia. Nutrients and natural food components have been investigated as preventive and/ or intervention strategy. Among candidate components, resveratrol, curcumin, and their analogues might be beneficial for the prevention of diabetes-related cognitive impairment. The purposes of this review are to discuss recent experimental evidence regarding diabetes and cognitive impairment and to suggest potential nutritional intervention strategies for the prevention and/or treatment of diabetes-related dementia.
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등록된 정보가 없습니다.
참고문헌 (72)
참고문헌 신청
Achari AE / 2017 / Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction / Int J Mol Sci 18:1321
Feve B / 2009 / The role of interleukins in insulin resistance and type 2 diabetes mellitus / Nat Rev Endocrinol 5:305~311
Akash MS / 2018 / Tumor necrosis factor-alpha: role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus / J Cell Biochem 119:105~110
Hemmingsen B / 2017 / Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus / Cochrane Database Syst Rev
Lawson TB / 2018 / Hyperglycemia Alters the Structure and Hemodynamics of the Developing Embryonic Heart / J Cardiovasc Dev Dis 5:E13
Feve B / 2009 / The role of interleukins in insulin resistance and type 2 diabetes mellitus / Nat Rev Endocrinol 5:305~311
Akash MS / 2018 / Tumor necrosis factor-alpha: role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus / J Cell Biochem 119:105~110
Hemmingsen B / 2017 / Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus / Cochrane Database Syst Rev
Lawson TB / 2018 / Hyperglycemia Alters the Structure and Hemodynamics of the Developing Embryonic Heart / J Cardiovasc Dev Dis 5:E13
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