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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.18 No.3
- 발행연도
- 2018.1
- 수록면
- 157 - 161 (5page)
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초록· 키워드
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Liquid biopsy, the analysis of circulating biomarkers from peripheral blood, such as circulating tumor cells (CTCs) and circulating tumor DNA, and exosomes, offers a less invasive, new source of cancer-derived materials that may reflect the status of the disease better and thereby contribute to personalized treatment. Recent advances in microfluidics and molecular analysis technologies have resulted in greatly improved CTC enumeration and detection. In this article, we review commercially available technologies used to isolate CTCs from peripheral blood, including immunoaffinity and label-free, physical property-based isolation methods. Although enormous technological progress has been made, especially within the last decade, only a few CTC detection methods have been approved for routine clinical use. Here, we provide an overview of the current CTC isolation methods and examples of their potential application for early diagnosis, prognosis, treatment monitoring, and prediction of resistance to cancer therapy. Furthermore, the challenges that remain to be addressed before such tools are implemented for routine use in clinical settings are discussed. (Korean J Helicobacter Up Gastrointest Res 2018;18:-161)
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참고문헌 (28)
참고문헌 신청
Maheswaran S / 2010 / Circulating tumor cells: a window into cancer biology and metastasis / Curr Opin Genet Dev 20:96~99
Riethdorf S / 2007 / Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system / Clin Cancer Res 13:920~928
Miller MC / 2010 / Significance of circulating tumor cells detected by the Cellsearch system in patients with metastatic breast colorectal and prostate cancer / J Oncol 2010:617421
Harb W / 2013 / Mutational analysis of circulating tumor cells using a novel microfluidic collection device and qPCR Assay / Transl Oncol 6:528~538
Desitter I / 2011 / A new device for rapid isolation by size and characterization of rare circulating tumor cells / Anticancer Res 31:427~441
Riethdorf S / 2007 / Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system / Clin Cancer Res 13:920~928
Miller MC / 2010 / Significance of circulating tumor cells detected by the Cellsearch system in patients with metastatic breast colorectal and prostate cancer / J Oncol 2010:617421
Harb W / 2013 / Mutational analysis of circulating tumor cells using a novel microfluidic collection device and qPCR Assay / Transl Oncol 6:528~538
Desitter I / 2011 / A new device for rapid isolation by size and characterization of rare circulating tumor cells / Anticancer Res 31:427~441
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