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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.16 No.4
- 발행연도
- 2016.1
- 수록면
- 178 - 184 (7page)
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초록· 키워드
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For the last half century, vitamin K antagonists (VKAs) have been used for treatment and prevention of venous thromboembolism and stroke prevention in patients with atrial fibrillation. However, their fragile pharmacokinetics, need for routine laboratory monitoring and dose adjustments complicated the use of these drugs. Recently, new oral anticoagulants (NOACs) have overcome the limitation of VKA therapy and shows favorable outcomes and better safety, especially for patients with intracranial hemorrhage, both in phase III clinical trials and real-world registry. Currently available NOACs are one thrombin inhibitor, dabigatran, and three Xa inhibitors, rivaroxaban, apixaban, and edoxaban. This review covers the pharmacokinetics, published pivotal clinical trials, and dose adjustments in chronic kidney disease. The reimbursement criteria, discontinuation during elective surgical procedure, issues on reversal agents are also discussed.
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참고문헌 (52)
참고문헌 신청
Shapiro SS / 2003 / Treating thrombosis in the 21st century / N Engl J Med 349:1762~1764
Francis CW / 2003 / Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement / N Engl J Med 349:1703~1712
Connolly SJ / 2009 / Dabigatran versus warfarin in patients with atrial fibrillation / N Engl J Med 361:1139~1151
Patel MR / 2011 / Rivaroxaban versus warfarin in nonvalvular atrial fibrillation / N Engl J Med 365:883~891
Granger CB / 2011 / Apixaban versus warfarin in patients with atrial fibrillation / N Engl J Med 365:981~992
Francis CW / 2003 / Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement / N Engl J Med 349:1703~1712
Connolly SJ / 2009 / Dabigatran versus warfarin in patients with atrial fibrillation / N Engl J Med 361:1139~1151
Patel MR / 2011 / Rivaroxaban versus warfarin in nonvalvular atrial fibrillation / N Engl J Med 365:883~891
Granger CB / 2011 / Apixaban versus warfarin in patients with atrial fibrillation / N Engl J Med 365:981~992
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