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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 277 - 284 (8page)
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초록· 키워드
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Purpose: Label adherence for non-vitamin K antagonist oral anticoagulants (NOACs) has not been well evaluated in Asian patientswith non-valvular atrial fibrillation (AF). The present study aimed to assess label adherence for NOACs in a Korean AF populationand to determine risk factors of off-label prescriptions of NOACs. Materials and Methods: In this COmparison study of Drugs for symptom control and complication prEvention of AF (CODE-AF)registry, patients with AF who were prescribed NOACs between June 2016 and May 2017 were included. Four NOAC doses werecategorized as on- or off-label use according to Korea Food and Drug Regulations. Results: We evaluated 3080 AF patients treated with NOACs (dabigatran 27.2%, rivaroxaban 23.9%, apixaban 36.9%, and edoxaban12.0%). The mean age was 70.5±9.2 years; 56.0% were men; and the mean CHA2DS2-VASc score was 3.3±1.4. Only one-thirdof the patients (32.7%) was prescribed a standard dose of NOAC. More than one-third of the study population (n=1122, 36.4%)was prescribed an off-label reduced dose of NOAC. Compared to those with an on-label standard dosing, patients with an off-labelreduced dose of NOAC were older (≥75 years), women, and had a lower body weight (≤60 kg), renal dysfunction (creatinineclearance ≤50 mL/min), previous stroke, previous bleeding, hypertension, concomitant dronedarone use, and anti-platelet use. Conclusion: In real-world practice, more than one-third of patients with NOAC prescriptions received an off-label reduced dose,which could result in an increased risk of stroke. Considering the high risk of stroke in these patients, on-label use of NOAC is recommended.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ogilvie IM / 2010 / Underuse of oral anticoagulants in atrial fibrillation : a systematic review / Am J Med 123:638~645
Huisman MV / 2017 / The changing landscape for stroke prevention in AF : findings from the GLORIA-AF registry phase 2 / J Am Coll Cardiol 69:777~785
Camm AJ / 2017 / Evolving antithrombotic treatment patterns for patients with newly diagnosed atrial fibrillation / Heart 103:307~314
Lee SR / 2017 / Temporal trends of antithrombotic therapy for stroke prevention in Korean patients with non-valvular atrial fibrillation in the era of non-vitamin K antagonist oral anticoagulants : a nationwide populationbased study / PLoS One 12:e0189495
Connolly SJ / 2009 / Dabigatran versus warfarin in patients with atrial fibrillation / N Engl J Med 361:1139~1151
Huisman MV / 2017 / The changing landscape for stroke prevention in AF : findings from the GLORIA-AF registry phase 2 / J Am Coll Cardiol 69:777~785
Camm AJ / 2017 / Evolving antithrombotic treatment patterns for patients with newly diagnosed atrial fibrillation / Heart 103:307~314
Lee SR / 2017 / Temporal trends of antithrombotic therapy for stroke prevention in Korean patients with non-valvular atrial fibrillation in the era of non-vitamin K antagonist oral anticoagulants : a nationwide populationbased study / PLoS One 12:e0189495
Connolly SJ / 2009 / Dabigatran versus warfarin in patients with atrial fibrillation / N Engl J Med 361:1139~1151
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