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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 201 - 210 (10page)
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Injury to podocytes is an early event in diabetic nephropathy leading to proteinuria with possible progression to end-stage renal failure. The podocytes are unique and highly specialized cells that cover the outer layer of kidney ultrafiltration barrier and play an important role in glomerular function. In the past few decades, adult stem cells, such as mesenchymal stem cells (MSCs) with a regenerative and differentiative capacity have been extensively used in cell-based therapies. In addition to their capability for regeneration and differentiation, MSCs contributes to their milieu by paracrine action of a series of growth factors via antiapoptotic, mitogenic and other cytokine actions that actively participate in treatment of podocyte damage through prevention of podocyte effacement, detachment and apoptosis. It is hoped that novel stem cell-based therapies will be developed in the future to prevent podocyte injury, thereby reducing the burden of kidney disease.
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등록된 정보가 없습니다.
참고문헌 (95)
참고문헌 신청
Sarje SK / 2013 / Association of chronic complications of type 2 diabetes with the biochemical and physical estimations in subjects attending single visit screening for complications / Int J Res Pharm Chem 3:842~845
Hajiaghaalipour F / 2015 / Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus / Int J Biol Sci 11:508~524
Ezquer FE / 2008 / Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice / Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl 14:631~640
Bakris GL / 2000 / Preserving renal function in adults with hypertension and diabetes: a consensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group / Am J kidney Dis Off J Natl Kidney Found 36:646~661
Wolf G / 2005 / From the periphery of the glomerular capillary wall toward the center of disease : podocyte injury comes of age in diabetic nephropathy / Diabetes 54:1626~1634
Hajiaghaalipour F / 2015 / Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus / Int J Biol Sci 11:508~524
Ezquer FE / 2008 / Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice / Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl 14:631~640
Bakris GL / 2000 / Preserving renal function in adults with hypertension and diabetes: a consensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group / Am J kidney Dis Off J Natl Kidney Found 36:646~661
Wolf G / 2005 / From the periphery of the glomerular capillary wall toward the center of disease : podocyte injury comes of age in diabetic nephropathy / Diabetes 54:1626~1634
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