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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Salmonella enterica serovar Typhimurium is one of the most important bacterial pathogenscausing diarrhea. The resistance of S. typhimurium to antimicrobial agents, whichhas recently been isolated from patients, is causing serious problems. We investigatedthe effects of salicylic acid (Sal) and acetyl salicylate (AcSal) on the susceptibility ofS. typhimurium to cephalosporin antibiotics, which are known to increase resistanceto cephalosporin and quinolone antibiotics. The MIC of cephalosporin antibiotics washigher than that of the media without Sal. The rate of accumulation of ethidium bromide(EtBr) in the bacteria by the outer membrane protein (Omp) was not different fromthat of the bacteria cultured in the medium containing Sal. However, Carbonyl cyanide-m-chlorophenylhydrazone (CCCP), an inhibitor of bacterial efflux pumps, significantlyreduced the rate of accumulation of EtBr in bacteria cultured on Sal containingmedium. In the medium containing CCCP, the MIC of the antimicrobial agent tendedto decrease as compared with the control. In addition, the MIC of the bacteria treatedwith CCCP and Sal was higher than that of the antimicrobial agent against the CCCPtreated experimental bacteria. These results suggest that Sal decreases the expressionof OmpF in the Omp of S. typhimurium and reduces the permeability of cephalosporinantibiotics to bacteria, which may induce tolerance to cephalosporin antibiotics.
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참고문헌 (34)
참고문헌 신청
Cohen SP / 1989 / Cross-resistance to fluoroquinolones in multiple-antibiotic- resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction / Antimicrob Agents Chemother 33:1318~1325
Arlet G / 2006 / Salmonella resistant to extended-spectrum cephalosporins: prevalence and epidemiology / Microbes Infect 8:1945~1954
Baucheron S / 2004 / AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104 / Antimicrob Agents Chemother 48:3729~3735
Eaves DJ / 2004 / Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimurium: role in multiple antibiotic resistance / Antimicrob Agents Chemother 48:1145~1150
Medeiros AA / 1987 / Loss of OmpC porin in a strain of Salmonella typhimurium causes increased resistance to cephalosporins during therapy / J Infect Dis 156:751~757
Arlet G / 2006 / Salmonella resistant to extended-spectrum cephalosporins: prevalence and epidemiology / Microbes Infect 8:1945~1954
Baucheron S / 2004 / AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104 / Antimicrob Agents Chemother 48:3729~3735
Eaves DJ / 2004 / Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimurium: role in multiple antibiotic resistance / Antimicrob Agents Chemother 48:1145~1150
Medeiros AA / 1987 / Loss of OmpC porin in a strain of Salmonella typhimurium causes increased resistance to cephalosporins during therapy / J Infect Dis 156:751~757
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