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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 128 - 135 (8page)
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Statins and renin-angiotensin system (RAS) blockers are key drugs for treating patientswith an acute myocardial infarction (AMI). This study was designed to show theassociation between treatment with statins or RAS blockers and clinical outcomes andthe efficacy of two drug combination therapies in patients with ischemic heart failure(IHF) who underwent revascularization for an AMI. A total of 804 AMI patients witha left ventricular ejection fraction ＜40% who undertook percutaneous coronary interventions(PCI) were analyzed using the Korea Acute Myocardial Infarction Registry(KAMIR). They were divided into four groups according to the use of medications [GroupI: combination of statin and RAS blocker (n=611), Group II: statin alone (n=112), GroupIII: RAS blocker alone (n=53), Group IV: neither treatment (n=28)]. The cumulativeincidence of major adverse cardiac and cerebrovascular events (MACCEs) and independentpredictors of MACCEs were investigated. Over a median follow-up studyof nearly 1 year, MACCEs had occurred in 48 patients (7.9%) in Group I, 16 patients(14.3%) in Group II, 3 patients (5.7%) in Group III, 7 patients (21.4%) in Group IV(p=0.013). Groups using RAS blocker (Group I and III) showed better clinical outcomescompared with the other groups. By multivariate analysis, use of RAS blockers wasthe most powerful independent predictor of MACCEs in patients with IHF who underwentPCI (odds ratio 0.469, 95% confidence interval 0.285-0.772; p=0.003), but statintherapy was not found to be an independent predictor. The use of RAS blockers, butnot statins, was associated with better clinical outcomes in patients with IHF who underwent PCI.
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참고문헌 (23)
참고문헌 신청
Ridker PM / 2005 / Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy / N Engl J Med 352:20~28
Schwartz GG / 2001 / Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial / JAMA 285:1711~1718
WRITING COMMITTEE MEMBERS / 2013 / American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines / Circulation 128:e240~e327
Amsterdam EA / 2014 / ACC/AHA Task Force Members. 2014AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines / Circulation 130:e344~e426
O'Gara PT / 2013 / American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American college of cardiology foundation/American heart association task force on practice guidelines / Circulation 127:e362~e425
Schwartz GG / 2001 / Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial / JAMA 285:1711~1718
WRITING COMMITTEE MEMBERS / 2013 / American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines / Circulation 128:e240~e327
Amsterdam EA / 2014 / ACC/AHA Task Force Members. 2014AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines / Circulation 130:e344~e426
O'Gara PT / 2013 / American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American college of cardiology foundation/American heart association task force on practice guidelines / Circulation 127:e362~e425
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