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자료유형
학술저널
저자정보
김은란 (성균관대학교) 전자룡 (성균관대학교) 이진희 (성균관대학교) 이윤정 (성균관대학교) 홍성노 (삼성서울병원) 장동경 (삼성서울병원) 김영호 (성균관대학교)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.15 No.3
발행연도
2017.1
수록면
402 - 410 (9page)

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Background/Aims: Serrated polyposis syndrome (SPS) has been shown to increase the risk of colorectal cancer (CRC). However,little is known about the characteristics of Asian patients with SPS. This study aimed to identify the clinicopathologicalfeatures and risk of CRC in Korean patients with SPS as well as the differences between Korean and Western patients based ona literature review. Methods: This retrospective study included 30 patients with SPS as defined by World Health Organizationclassification treated at Samsung Medical Center, Korea, between March 1999 and May 2011. Results: Twenty patients (67%)were male. The median patient age at diagnosis was 56 years (range, 39–76 years). A total of 702 polyps were identified duringa median follow-up of 43 months (range, 0–149 months). Serrated polyps were noted more frequently in the distal colon(298/702, 55%). However, large serrated polyps and serrated adenomas were mainly distributed throughout the proximal colon(75% vs. 25% and 81% vs. 19%, respectively); 73.3% had synchronous adenomatous polyps. The incidence of CRC was 10%(3/30 patients), but no interval CRC was detected. A total of 87% of the patients underwent esophagogastroduodenoscopy and19.2% had significant lesions. Conclusions: The phenotype of SPS in Korean patients is different from that of Western patients. In Korean patients, SPS is more common in men, there were fewer total numbers of serrated adenoma/polyps, and the incidenceof CRC was lower than that in Western patients. Korean patients tend to more frequently have abnormal gastric lesions. However, the prevalence of synchronous adenomatous polyps is high in both Western and Korean patients.

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