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As industry develops in modern society, many chemicals are being used. The safety of chemicals is an important issue because humansare constantly exposed to chemicals throughout their daily life. Through a risk assessment, the hazardous human effects of chemicalscan be identified. Recently, the adverse outcome pathway (AOP) framework has been used to predict the adverse effects of chemicals. As a conceptual framework for organizing existing biological knowledge, the AOP consists of a molecular initiating event, key events,and an adverse outcome. These independent elements represent biological responses and are connected by key event relationships. ThisAOP framework provides intuitive hazard identification that can be helpful for carcinogenic risk assessment of chemicals. In this review,we introduce the application of the AOP framework to risk assessment for predicting carcinogenicity of chemicals and illustrate the utilityof this approach for cancer prevention.
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