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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 103 - 103 (1page)
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An adverse outcome pathway (AOP) is a framework that organizes the predictive relationships between molecular initiating events (MIEs), key events (KEs), and adverse outcomes (AOs), which contributes to providing evidence based mechanistic insights. Meanwhile, integrating and utilizing the massive and heterogeneous data from different biological levels is a laborious and time intensive process, brings a challenge in AOP’s construction. Fortunately, mining available publicly database through computational and bioinformatics approaches can make the mass of biological information into better serve as the basis for creating expert-derived AOPs in a much more efficient way. The Comparative Toxicogenomics Database (CTD, http://ctdbase.org/), as a comprehensive, continuously updated and publicly available database, provides manually curated associations between and among chemicals, genes, phenotypes, diseases captured from the scientific literatures. The chemical-phenotype module of CTD provides numerous opportunities for users to unravel the complex interaction between environmental exposure and molecular and functional changes in organisms. As a part of OECD AOP program, the AOP Wiki (http://aopkb.org) serves as the pr ... 전체 초록 보기
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