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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 141 - 158 (18page)
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초록· 키워드
오류제보하기
Objectives: An adverse outcome pathway is a biological pathway that disturbs homeostasis and causes toxicity. It is a conceptual framework for organizing existing biological knowledge and consists of the molecular initiating event, key event, and adverse output. The AOP concept provides intuitive risk identification that can be helpful in evaluating the carcinogenicity of chemicals and in the prevention of cancer through the assessment of chemical carcinogenicity predictions. Methods: We reviewed various papers and books related to the application of AOPs for the prevention of occupational cancer. We mainly used the internet to search for the necessary research data and information, such as via Google scholar(http://scholar.google.com), ScienceDirect(www.sciencedirect.com), Scopus(www.scopus. com), NDSL(http: //www.ndsl.kr/index.do) and PubMed(http://www.ncbi.nlm.nih.gov/pubmed). The key terms searched were "adverse outcome pathway," "toxicology," "risk assessment," "human exposure," "worker," "nanoparticle," "applications," and "occupational safety and health," among others. Results: Since it focused on the current state of AOP for the prediction of toxicity from chemical exposure at work and prospects for industrial health in the context of the AOP concept, respiratory and nanomaterial hazard assessments. AOP provides an intuitive understanding of the toxicity of chemicals as a conceptual means, and it works toward accurately predicting chemical toxicity. The AOP technique has emerged as a future-oriented alternative to the existing paradigm of chemical hazard and risk assessment. AOP can be applied to the assessment of chemical carcinogenicity along with efforts to understand the effects of chronic toxic chemicals in workplaces. Based on these predictive tools, it could be possible to bring about a breakthrough in the prevention of occupational and environmental cancer. Conclusions: The AOP tool has emerged as a future-oriented alternative to the existing paradigm of chemical hazard and risk assessment and has been widely used in the field of chemical risk assessment and the evaluation of carcinogenicity at work. It will be a useful tool for prediction, and it is possible that it can help bring about a breakthrough in the prevention of occupational and environmental cancer.
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참고문헌 (93)
참고문헌 신청
Timothy E. H. Allen / 2014 / Defining Molecular Initiating Events in the Adverse Outcome Pathway Framework for Risk Assessment / Chemical Research in Toxicology 27(12):2100~2112
American Cancer Society(ACS) / Known and probable human carcinogens
Melvin E. Andersen / 2010 / The Future of Toxicity Testing / Journal of Toxicology and Environmental Health, Part B 13(2-4):163~196
Gerald T. Ankley / 2010 / Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment / Environmental Toxicology and Chemistry 29(3):730~741
Anna Bal-Price / 2017 / Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity / NeuroToxicology 59:240~255
American Cancer Society(ACS) / Known and probable human carcinogens
Melvin E. Andersen / 2010 / The Future of Toxicity Testing / Journal of Toxicology and Environmental Health, Part B 13(2-4):163~196
Gerald T. Ankley / 2010 / Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment / Environmental Toxicology and Chemistry 29(3):730~741
Anna Bal-Price / 2017 / Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity / NeuroToxicology 59:240~255
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