Anti-inflammatory and Anti-tumorigenic Effects of Açai Berry in Helicobacter felis-infected mice

이주엽; 김나영; 최윤정; 남령희; 이선민; 함민희; 서지형; 최윤진; 이혜승; 이동호

추천

검색

자료유형: 학술저널

저자정보: 이주엽 (계명대학교) 김나영 (서울대학교) 최윤정 (서울대학교) 남령희 (분당서울대학교병원) 이선민 (서울대학교) 함민희 (서울대학교) 서지형 (분당서울대학교병원) 최윤진 (분당서울대학교병원) 이혜승 (분당서울대학교병원) 이동호 (서울대학교)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제21권 제1호

발행연도: 2016.1

수록면: 48 - 54 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: The aim of this study was to evaluate the anti-inflammatory and anti-tumorigenic effect of açai berry after chronic Helicobacter felis colonization in the stomachs of C57BL/6 mice. Methods: A total of 57 four-week-old female C57BL/6 mice (18 control mice and 39 experimental mice) were used. The mice were administered orogastrically with vehicle only or vehicle containing H. felis, 5 times every other day. After inoculation of H. felis, mice were fed either a standard or an açai-containing diet and then sacrificed at 4, 24, and 52 weeks. The infection status and degree of inflammation were determined by culture and histopathology. The level of gastric mucosal myeloperoxidase (MPO), TNF-α, and interleukin-1β (IL-1β) were measured by ELISA. Results: At 24 weeks after inoculation, mucosal atrophy and mucous metaplasia appeared in all infected mice. At 52 weeks after inoculation, dysplastic change was noted in 10%, 25%, and 50% of mice in the H. felis-control, H. felis-açai 5%, and H. felis-açai 10% groups, respectively. The neutrophil, monocyte, atrophy, and metaplasia grades of infected mice showed no significant difference among the H. felis-infected groups. H. felis-infected mice fed with açai berry showed no significant difference compared with H. felis-infected control mice in gastric mucosal MPO, TNF-α, and IL-1β levels. Conclusions: H. felis that colonized the stomachs of C57BL/6 mice provoked inflammation, and induced mucosal atrophy, metaplasia, and dysplasia. However, açai berry did not effectively prohibit the gastric carcinogenesis which was induced by chronic H. felis infection.

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Ju Yup Lee

소속기관 Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea

주요연구분야 의약학 > 의학 일반 의약학 > 기초의학 > 예방의학·직업환경의학

논문수 48 이용수 116

Kim Nayoung

소속기관 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of