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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
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- 1 - 8 (8page)
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Objective: In 2014 World Health Organization criteria, seromucinous carcinoma was defined as a new histological subtype in ovarian carcinomas, but “seromucinous carcinoma” was not defined in endometrial carcinomas. The aim of this study was to identify seromucinous carcinoma resembling ovarian seromucinous carcinoma in endometrial carcinomas, and to evaluate the clinical significance for prognoses of the patients. Methods: Central pathological review was conducted for patients with endometrioid carcinoma of the endometrium treated by primary surgery at our hospital between 1990 and 2013. Results: Among 340 cases included in the study, no case had all tumor cells resembling ovarian seromucinous carcinoma in all specimens, and 31 cases (9.1%) had seromucinous component in combination with endometrioid carcinomas. Immunohistochemical analysis revealed seromucinous component had positive reactivity for cytokeratin (CK) 7, and negative reactivity for CK20 and caudal type homeobox 2 (CDX2) in all cases. Seromucinous component showed lower immunoreactivity of estrogen receptor and progesterone receptor, compared with endometrioid carcinoma component. Progression-free survival of the cases with seromucinous component was better than those without seromucinous component (p=0.049). Conclusion: Seromucinous component was identified in approximately 10% of endometrioid carcinoma, and could be a histological predictor for prognosis.
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참고문헌 (9)
참고문헌 신청
Wartko P / 2013 / Recent changes in endometrial cancer trends among menopausal-age U.S. women / Cancer Epidemiol 37:374~377
Pecorelli S / 2009 / Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium / Int J Gynaecol Obstet 105:103~104
Kurman RJ / 2014 / WHO classification of tumours of female reproductive organs / International Agency for Research on Cancer
Shappell HW / 2002 / Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas / Am J Surg Pathol 26:1529~1541
Taylor J / 2015 / Ovarian seromucinous carcinoma: report of a series of a newly categorized and uncommon neoplasm / Am J Surg Pathol 39:983~992
Pecorelli S / 2009 / Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium / Int J Gynaecol Obstet 105:103~104
Kurman RJ / 2014 / WHO classification of tumours of female reproductive organs / International Agency for Research on Cancer
Shappell HW / 2002 / Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas / Am J Surg Pathol 26:1529~1541
Taylor J / 2015 / Ovarian seromucinous carcinoma: report of a series of a newly categorized and uncommon neoplasm / Am J Surg Pathol 39:983~992
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