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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제55권 제1호
- 발행연도
- 2021.1
- 수록면
- 43 - 52 (10page)
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초록· 키워드
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Background: The accurate pathologic diagnosis and subtyping of high-grade endometrial carcinoma are often problematic, due to its atypical and overlapping histopathological features. Methods: Three pathologists reviewed 21 surgically resected cases of advancedstage endometrial carcinoma. The primary diagnosis was based only on hematoxylin and eosin stained slides. When a discrepancy arose, a secondary diagnosis was made by additional review of immunohistochemical (IHC) stains. Finally, three pathologists discussed all cases and rendered a consensus diagnosis. Results: The primary diagnoses were identical in 13/21 cases (62%). The secondary diagnosis based on the addition of IHC results was concordant in four of eight discrepant cases. Among four cases with discrepancies occurring in this step, two cases subsequently reached a consensus diagnosis after a thorough discussion between three reviewers. Next-generation sequencing (NGS) study was performed in two cases in which it was difficult to distinguish between serous carcinoma and endometrioid carcinoma. Based on the sequencing results, a final diagnosis of serous carcinoma was rendered. The overall kappa for concordance between the original and consensus diagnosis was 0.566 (moderate agreement). Conclusions: We investigated stepwise changes in interobserver diagnostic reproducibility in advanced-stage endometrial carcinoma. We demonstrated the utility of IHC and NGS study results in the histopathological diagnosis of advanced-stage endometrial carcinoma.
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참고문헌 (20)
참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
임명철 / 2019 / Incidence of cervical, endometrial, and ovarian cancer in Korea during 1999–2015 / Journal of Gynecologic Oncology 30(1):1~8
Kurman RJ / 2014 / WHO classification of tumours of female reproductive organs / IARC Press
Bokhman JV / 1983 / Two pathogenetic types of endometrial carcinoma / Gynecol Oncol 15:10~17
Wang J / 2016 / Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma / Oncol Lett 12:2860~2867
임명철 / 2019 / Incidence of cervical, endometrial, and ovarian cancer in Korea during 1999–2015 / Journal of Gynecologic Oncology 30(1):1~8
Kurman RJ / 2014 / WHO classification of tumours of female reproductive organs / IARC Press
Bokhman JV / 1983 / Two pathogenetic types of endometrial carcinoma / Gynecol Oncol 15:10~17
Wang J / 2016 / Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma / Oncol Lett 12:2860~2867
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